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NCI Drug Dictionary


plerixafor  Patient Information
A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Mozobil
Code names:AMD 3100
LM-3100
Chemical structures:1,1'-[1,4-phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
bis(tetraazacyclotetradecane) derivative