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NCI Drug Dictionary

  

CB10-277 
A synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Chemical structure:1-p-carboxy-3,3-dimethylphenyltriazine