In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary

NCI Drug Dictionary

  

sulindac 
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:Sulindac Sulfoxide
US brand names:Aflodac
Clinoril
Foreign brand names:Algocetil
Apo-Sulin
Arthrocine
Artribid
Citireuma
Clisundac
Imbaral
Novo-Sundac
Reumofil
Reumyl
Sudac
Sulinol
Sulreuma
Abbreviation:SULIN
Code name:MK-231
Chemical structures:(Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid