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NCI Drug Dictionary

NCI Drug Dictionary

  

plicamycin 
An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:aureolic acid
mithramycin
US brand name:Mithracin
Foreign brand name:Mithracine
Abbreviation:MTH
Code names:A-2371
PA-144