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NCI Drug Dictionary

  

plicamycin 
An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:aureolic acid
mithramycin
US brand name:Mithracin
Foreign brand name:Mithracine
Abbreviation:MTH
Code names:A-2371
PA-144