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NCI Drug Dictionary

NCI Drug Dictionary

  

gimeracil 
A pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:chlorodihydroxypyridine
Abbreviation:CDHP
Chemical structure:5-chloro-2,4-dihydroxypyridinediol