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NCI Drug Dictionary

  

WT1 mRNA-electroporated autologous dendritic cell vaccine 
A cancer vaccine containing autologous dendritic cells electroporated with full-length mRNA encoding Wilms' tumor 1 (WT1) antigen with potential immunostimulatory and antineoplastic activities. Upon administration, WT1 mRNA-electroporated autologous dendritic cell vaccine may elicit a cytotoxic T-cell (CTL) response against tumor cells expressing WT1. Wt1 is frequently overexpressed in a variety of tumor cell types and often correlates with disease progression and poor prognosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:Wilms tumor 1 mRNA-electroporated autologous dendritic cell vaccine