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NCI Drug Dictionary


A difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. Diflunisal competitively inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and subsequently blocks the conversion of arachidonic acid to prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. Diflunisal differs from other salicylates, in that it is not metabolized to salicylic acid, hence it has a longer half-life. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Dolobid
Foreign brand names:Apo-Diflunisal
Chemical structures:(1,1'-biphenyl)-3-carboxylic acid, 2',4'-difluoro-4-hydroxy-
2',4'-difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxylic acid