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NCI Drug Dictionary

NCI Drug Dictionary

  

oxcarbazepine 
A dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Trileptal
Chemical structure:10,11-dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide