Questions About Cancer? 1-800-4-CANCER

NCI Dictionary of Genetics Terms

NCI Dictionary of Genetics Terms

frameshift mutation


An insertion or deletion involving a number of base pairs that is not a multiple of three, which consequently disrupts the triplet reading frame of a DNA sequence. Such mutations usually lead to the creation of a premature termination (stop) codon, and result in a truncated (shorter-than-normal) protein product.

More Information