NCI Dictionary of Genetics Terms
single-stranded conformation polymorphism analysis
(SIN-gul-STRAN-ded KON-for-MAY-shun PAH-lee-MOR-fih-zum uh-NA-lih-sis)
A laboratory test used to separate single-stranded nucleic acids based on subtle differences in their DNA sequence, often a single base pair, which results in a different secondary structure and a measurable difference in mobiity through a gel. Also called SSCP analysis.