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NCI Dictionary of Genetics Terms


4 results found for: V



  • variable expression  listen  (VAYR-ee-uh-bul ek-SPREH-shun)
    Variation in the manner in which a trait is manifested. When there is variable expressivity, the trait may vary in clinical expression from mild to severe. For example, the condition neurofibromatosis type 1 may be mild, presenting with café-au-lait spots only, or may be severe, presenting with neurofibromas and brain tumors.

  • variant of uncertain significance  listen  (VAYR-ee-unt … un-SER-tin sig-NIH-fih-kunts)
    A variation in a genetic sequence whose association with disease risk is unknown. Also called unclassified variant, variant of unknown significance, and VUS.

  • variant of unknown significance  listen  (VAYR-ee-unt … UN-none sig-NIH-fih-kunts)
    A variation in a genetic sequence whose association with disease risk is unknown. Also called unclassified variant, variant of uncertain significance, and VUS.

  • VUS 
    A variation in a genetic sequence whose association with disease risk is unknown. Also called unclassified variant, variant of uncertain significance, and variant of unknown significance.