National Cancer Institute NCI Cancer Bulletin: A Trusted Source for Cancer Research News
April 6, 2010 • Volume 7 / Number 7


A dutasteride soft capsule and its packagingDutasteride Decreases Prostate Cancer Risk

Results from a large, randomized clinical trial indicate that men at an increased risk for prostate cancer reduced their risk with regular use of the drug dutasteride (Avodart). The results came from the REDUCE trial, which is the second large clinical trial to demonstrate a decreased risk of prostate cancer in men taking an agent from the class of drugs known as 5-α reductase inhibitors (5-αRIs). Previously, the Prostate Cancer Prevention Trial (PCPT) showed that the drug finasteride had a risk reduction similar to what has now been seen in REDUCE. Read more > >


Dr. James H. DoroshowGuest Director's Update: Improving the Efficiency of Clinical Trials— Decreasing Activation Times by Fifty Percent

by Dr. James H. Doroshow

NCI is dedicated to bringing new therapeutic and diagnostic options to patients with cancer as quickly as possible. On average, 25,000 to 30,000 patients per year are accrued to NCI-supported clinical trials through several networks of institutions and clinical trialists. However, the current process of activating new phase III clinical trials conducted by NCI’s cooperative groups averages more than 2 years; and the time to activate most phase I and II studies requires more than 500 days. A recent analysis of NCI’s clinical trials activation process demonstrated that many trials, especially those that took the longest to open, never reached their accrual goals and had to be closed, wasting precious time and resources. The analysis also showed that the complex path to trial activation was characterized by steps that did not ultimately add value to the clinical trial itself. Read more > >

Guest Commentary by Ambassador Nancy Brinker: Collaborating Globally to Address Breast Cancer in Latin America

The founder and CEO of Susan G. Komen for the Cure describes a partnership between her organization and NCI to address breast cancer issues in Latin American countries. Read more > >

A Conversation with Dr. Robert T. Croyle on Communicating Science

The Director of NCI’s Division of Cancer Control and Population Sciences talks about communicating health data clearly Read more > >



Coverage of AACR Annual Meeting

AACR Annual Meeting banner The American Association for Cancer Research 101st Annual Meeting will take place April 17–21 in Washington, DC. Look for highlights from the meeting in the April 20 issue of the NCI Cancer Bulletin.



  • Legislative Update

    • House Committee Convenes Hearing on NCI Research
  • FDA Update

    • New Tobacco Products Advisory Committee Focuses on Menthol Cigarettes
    • Advisory Panel Recommends Restrictions on Tanning Bed Use by Minors
  • Notes

    • Take Part in SELECT Biorepository Symposium
    • Meet NCI Experts at AACR
    • Tutorial on Targeted Therapies for Multiple Myeloma Available Online
  • Correction

    An article in the March 9 issue of the NCI Cancer Bulletin on the potential cardiac side effects of some cancer therapies reported that a clinical trial involving the drug bevacizumab (Avastin) was temporarily halted by the FDA. The article should have stated that enrollment to the trial was temporarily halted, not the dosing of patients already enrolled in the trial. The original article has been corrected. More information on the trial is available here.

Selected articles from past issues of the NCI Cancer Bulletin are available in Spanish.

The NCI Cancer Bulletin is produced by the National Cancer Institute (NCI), which was established in 1937. Through basic, clinical, and population-based biomedical research and training, NCI conducts and supports research that will lead to a future in which we can identify the environmental and genetic causes of cancer, prevent cancer before it starts, identify cancers that do develop at the earliest stage, eliminate cancers through innovative treatment interventions, and biologically control those cancers that we cannot eliminate so they become manageable, chronic diseases.

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