National Cancer Institute NCI Cancer Bulletin: A Trusted Source for Cancer Research News
April 17, 2012 • Volume 9 / Number 8


Targeted Nanoparticle Tested in Patients with Cancer

Artist's rendering of BIND-014. Illustration by Gaël McGill, Digizyme, Inc.

The first trial to test a targeted nanoparticle capable of controlling a drug's release is now under way in humans. By packaging molecules of the chemotherapy drug docetaxel in nanoparticles, researchers aim to deliver a higher dose of the drug directly to tumors and to reduce the toxicity to patients. 

In animal studies performed before the trial, the nanoparticle delivered a greater amount of the drug to tumor cells than could be achieved with the unpackaged (or free) drug. In addition, the nanoparticle did not show any more toxicity than docetaxel on its own.

Researchers from the Massachusetts Institute of Technology (MIT), Brigham and Women's Hospital, Harvard Medical School, BIND Biosciences, Inc., and their colleagues reported the development of the nanoparticle, called BIND-014, in the April 4 Science Translational Medicine. Read more > >



  • Legislative Update

    • Latest State Cancer Legislative Database Update Now Available
  • CDC Update

    • Calls to Tobacco Quitline Hit Record High after Launch of National Ad Campaign
  • Notes

    • Free Telephone Workshop Series for Cancer Survivors Begins April 24
    • Public Comment Sought on Draft Statement on Ovarian Cancer Screening
    • Apply to Visiting Scholars Program at Frederick National Laboratory by May 11
    • Applications for Oncology Fellowships Due May 31
    • NCI Requests Targets for Monoclonal Antibody Production and Characterization

Selected articles from past issues of the NCI Cancer Bulletin are available in Spanish.

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