Treating Colorectal Cancer Liver Metastases
Name of the Trial
Why This Trial Is Important
In this trial, colorectal cancer patients with six or fewer hepatic metastases will undergo primary surgery and/or ablation and then be treated with oxaliplatin and capecitabine. Half of the patients will receive additional chemotherapy consisting of floxuridine pumped directly into their livers through an arterial catheter and pump. This treatment, known as hepatic arterial infusion, delivers a very high concentration of chemotherapy directly to the site of the tumors. Because floxuridine is readily metabolized by the liver, side effects in other parts of the body are rare.
"The addition of hepatic infusion chemotherapy to standard systemic chemotherapy has helped prolong the lives of patients with liver metastases that could not be removed," said Dr. Wagman. "With this trial, we want to extend this treatment to patients with tumors that can be removed and see if it will help those patients live longer without recurrence of their cancer, and possibly result in a cure for some of them."
Who Can Join This Trial
Study Sites and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.