Comparing Treatments for Chronic Myelogenous Leukemia
Name of the Trial
Why This Trial Is Important
However, imatinib does not work for some patients, and it sometimes stops working if CML cells develop resistance to it. Therefore, researchers are interested in determining whether the standard dose of imatinib used as initial therapy for CML should be changed, or if a different targeted drug might be more effective.
In this trial, doctors will compare the effectiveness of imatinib at the standard dose versus an increased dose and against a new drug called dasatinib (Sprycel). Dasatinib binds to the Bcr-Abl protein more readily than imatinib and has demonstrated the ability to kill CML cells that have become resistant to imatinib.
“The current standard treatment for CML is 400 mg of imatinib a day,” said Dr. Druker, “and that produces a response in about 90 percent of patients. Treatment for this disease is evolving rapidly, however, and newer, more potent drugs are now available. With this trial, we hope to define the best treatment options for patients newly diagnosed with CML.”
Who Can Join This Trial
Study Sites and Contact Information
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