NCI Cancer Bulletin: A Trusted Source for Cancer Research NewsNCI Cancer Bulletin: A Trusted Source for Cancer Research News
February 20, 2007 • Volume 4 / Number 8 E-Mail This Document  |  Download PDF  |  Bulletin Archive/Search  |  Subscribe

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Featured Article

Link Between 1p36 Deletions and Cancer Revealed

A team of scientists at Cold Spring Harbor Laboratory and Stanford University has identified a tumor-suppressor function for Chd5, a member of the chromatin remodeling protein (CHD) family that maps to the 1p36 region of human chromosome 1. Their results are published February 9 in Cell.

Mutations in 1p36 are coincident with many diseases, including neural cancers, melanoma, hematopoietic cancers, and epithelial cancers of the thyroid, cervix, colon, and breast. These mutations are usually deletions, sparking a widespread search for a tumor suppressor as the missing link.  Read more  

Director's Update

Guest Update by Dr. Anna Barker

Dr. Anna Barker, NCI Deputy Director for Advanced Technologies and Strategic Partnerships Mapping the Cancer Genome

The following captures some of the highlights from an article in the March 2007 Scientific American magazine that I wrote with National Human Genome Research Institute (NHGRI) Director Dr. Francis Collins. It represents one of the first detailed discussions of The Cancer Genome Atlas in a publication that is widely read by a variety of audiences.

Writing in Science in 1986, Dr. Renato Dulbecco, a pioneering cancer researcher and Nobel Laureate declared, "We are at a turning point." Discoveries in preceding years had made clear that much of the deranged behavior of cancer cells stemmed from damage to their genes and alterations in their functioning. "We have two options," he wrote. "Either try to discover the genes important in malignancy by a piecemeal approach, or…sequence the whole genome."  Read more  

The NCI Cancer Bulletin is produced by the National Cancer Institute (NCI). NCI, which was established in 1937, leads the national effort to eliminate the suffering and death due to cancer. Through basic, clinical, and population-based biomedical research and training, NCI conducts and supports research that will lead to a future in which we can identify the environmental and genetic causes of cancer, prevent cancer before it starts, identify cancers that do develop at the earliest stage, eliminate cancers through innovative treatment interventions, and biologically control those cancers that we cannot eliminate so they become manageable, chronic diseases.

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