Cilengitide for PSA-Only Progressive Prostate Cancer
Name of the Trial
Why This Trial Is Important
Measuring the level of prostate-specific antigen (PSA) in the blood is often used to determine the response of prostate cancer to treatment. A rising PSA level may indicate that active cancer cells remain in the body despite previous treatments to remove or destroy them. Often, a rising PSA level is the only signal that prostate cancer is still growing (PSA-only progression).
In this trial, men with PSA-only progression despite antiandrogen therapy will be treated with a drug called cilengitide. Cilengitide blocks receptor proteins called integrins on the surface of prostate cancer cells that may play a role in the ability of these cells to enter and exit the bloodstream, attach at potential sites of metastasis, and promote the formation of new blood vessels (angiogenesis). PSA level stabilization or decline would indicate that cilengitide can help control prostate cancer growth in these patients.
"Men with this stage of advanced prostate cancer are incurable and no standard treatment exists," said Dr. Hussain. "Our hope is that cilengitide can help contain micrometastatic cancer cells by preventing their spread and adhesion to bone, which is the most common site of prostate cancer metastasis, and by stopping their potential to establish new blood vessels."
Who Can Join This Trial
Study Sites and Contact Information
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