Radiation Therapies to Treat Brain Metastases
Name of the Trial
Why This Trial Is Important
Whole-brain radiotherapy and stereotactic radiosurgery are methods that have proven useful in treating brain metastases. In whole-brain radiotherapy, radiation is delivered to the entire brain in incremental doses over the course of a few weeks. In stereotactic radiosurgery, radiation is delivered in a higher single dose directly to the tumor, minimizing the exposure of normal brain cells to harmful radiation.
In this trial, doctors are comparing stereotactic radiosurgery alone with stereotactic radiosurgery followed by whole-brain radiotherapy. They want to determine whether adding whole-brain radiotherapy provides any benefit in terms of preventing additional metastases and how whole-brain radiotherapy affects patient quality of life and cognition.
"Upfront whole-brain radiotherapy is a proven method of preventing brain metastases, but its benefits may come at the cost of reduced cognitive abilities and quality of life," said Dr. Brown. "So the role of whole-brain radiotherapy in this setting remains controversial. With this trial, we hope to define its use in the treatment of brain metastases following radiosurgery."One recent development that we're excited about is a trial amendment that allows the use of pinless head systems to deliver the radiosurgery, which will open the study up to many more treatment centers."
Who Can Join This Trial
Study Sites and Contact Information
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