Brain Cancer Study Explores Multi-Targeted Therapies
Targeted drugs such as imatinib (Gleevec) and erlotinib (Tarceva) have been tested against brain cancer, but few patients have benefited. A new study offers a possible explanation for the disappointing results and suggests that using the drugs in combination may be a more effective strategy against the deadly disease.
The researchers found that brain cancer cells may simultaneously activate a number of proteins on the cell surface called receptor tyrosine kinases, or RTKs. These proteins relay growth-promoting signals into cells, sustaining their survival. RTKs have become popular drug targets because they are frequently overactive or mutated.
In Memory of Dr. Martin Abeloff
Dr. Martin Abeloff
On Friday, September 14, 2007, the cancer community lost one of its truly outstanding leaders. Dr. Martin Abeloff, who directed the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University for the last 15 years, died after a year-long battle with leukemia.
He was among the finest clinician/researchers I have ever met. His legacy will be marked by his personal success as a leader in translational research, particularly with regard to the adjuvant treatment of breast cancer. Dr. Abeloff also was a proponent of cancer prevention and control research, establishing a formal program at Kimmel for research in early disease biomarkers and disease surveillance.
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