Targeted Combinations for Metastatic Kidney Cancer
Name of the Trial
Why This Trial Is Important
Two drugs that target multiple tyrosine kinase proteins - sorafenib and sunitinib - and the drug temsirolimus, which inhibits a protein called mTOR, have been approved by the FDA for advanced kidney cancer. Additionally, treatment with a biological agent called bevacizumab, which inhibits the growth of new blood vessels (angiogenesis) to tumors by targeting a protein called VEGF, has shown promising results in a phase III trial. While all of these agents are effective in delaying the progression of kidney cancer, none are yet curative for advanced disease, and the relative importance of the molecular targets of these drugs in the biology of kidney tumors is not yet known.
In this trial, doctors are testing different combinations of bevacizumab, sorafenib, and temsirolimus in patients with metastatic kidney cancer. Like bevacizumab, sorafenib and temsirolimus inhibit angiogenesis, but they also inhibit other processes thought to be important in kidney cancer progression.
"In this trial, we're testing three different combinations of these agents against each other and against single-agent therapy with bevacizumab," said Dr. Flaherty. "We're trying to determine which combination looks most promising, so we can advance it to a phase III clinical trial that might establish the standard of care for this disease."
Who Can Join This Trial
Study Site and Contact Information
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