NCI Cancer Bulletin: A Trusted Source for Cancer Research NewsNCI Cancer Bulletin: A Trusted Source for Cancer Research News
May 13, 2008 • Volume 5 / Number 10 E-Mail This Document  |  Download PDF  |  Bulletin Archive/Search  |  Subscribe

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Featured Article

Genome Scans Find Clues to Childhood Cancer

In the first genome-wide association study of a rare cancer, researchers have identified common genetic variants that may increase the risk of neuroblastoma, a childhood cancer of the nervous system.

Risk factors for the more aggressive forms of neuroblastoma may reside on a region of chromosome 6, according to a report published online last week in the New England Journal of Medicine (NEJM). The region was not previously linked to the disease.

Little has been known about susceptibility to neuroblastoma. The disease often begins in early childhood (or before birth) and initially affects the nerve tissue of the adrenal glands. Many researchers have thought that mutations in several major genes would largely determine the inherited component of the disease.   Read more  

Clinical Research Highlights

Mammography Plus Breast Ultrasound Yields Mixed Results

First-year screening data from a study comparing ultrasound with or in addition to mammography in women who have increased breast cancer risk indicate that combining the two tests has benefits and drawbacks.

Adding a screening ultrasound to routine mammography revealed 28 percent more cancers than mammography alone. However, the addition of ultrasound to mammography also resulted in a fourfold increase in false-positive findings - that is, screening results leading to a biopsy that revealed no cancer.   Read more  

The NCI Cancer Bulletin is produced by the National Cancer Institute (NCI). NCI, which was established in 1937, leads the national effort to eliminate the suffering and death due to cancer. Through basic, clinical, and population-based biomedical research and training, NCI conducts and supports research that will lead to a future in which we can identify the environmental and genetic causes of cancer, prevent cancer before it starts, identify cancers that do develop at the earliest stage, eliminate cancers through innovative treatment interventions, and biologically control those cancers that we cannot eliminate so they become manageable, chronic diseases.

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