NCI Cancer Bulletin: A Trusted Source for Cancer Research NewsNCI Cancer Bulletin: A Trusted Source for Cancer Research News
July 8, 2008 • Volume 5 / Number 14 E-Mail This Document  |  Download PDF  |  Bulletin Archive/Search  |  Subscribe

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Featured Article

Workshop Opens Dialogue on Cancer Clinical Trials

Experts on clinical trials met last week to share ideas about how to improve a system that has served the nation well for decades but needs to be modified and updated to meet the needs of patients and its many stakeholders.

A major theme of this workshop was that the reform must be global and include regulatory agencies, third-party payers, and funding entities, such as NCI and pharmaceutical companies, noted NCI Director Dr. John Niederhuber, who delivered opening remarks.  Read more  

Clinical Research Highlights

Androgen Deprivation No Better than Conservative Approach in Localized Prostate Cancer

Using androgen deprivation therapy alone in older men with localized prostate cancer does not improve survival outcomes when compared with a conservative management approach, according to a new analysis in the July 8 Journal of the American Medical Association. For localized prostate cancer, androgen deprivation therapy has become a common treatment, despite a lack of definitive evidence that it is more effective than other options, noted the study authors.

To conduct the study, the researchers, from The Cancer Institute of New Jersey, used data from NCI's Surveillance, Epidemiology, and End Results (SEER) program and linked Medicare files to compare the outcomes in men aged 66 and older, who were diagnosed with localized prostate cancer between 1992 and 2002 and had not undergone surgery. Of these men, nearly 8,000 received androgen deprivation therapy and approximately 11,400 were treated with conservative management, often called "watchful waiting."  Read more  

The NCI Cancer Bulletin is produced by the National Cancer Institute (NCI). NCI, which was established in 1937, leads the national effort to eliminate the suffering and death due to cancer. Through basic, clinical, and population-based biomedical research and training, NCI conducts and supports research that will lead to a future in which we can identify the environmental and genetic causes of cancer, prevent cancer before it starts, identify cancers that do develop at the earliest stage, eliminate cancers through innovative treatment interventions, and biologically control those cancers that we cannot eliminate so they become manageable, chronic diseases.

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