Virtual Colonoscopy Identifies Large Polyps
Results from the American College of Radiology Imaging Network (ACRIN) National CT Colonography Trial, published in the September 18 New England Journal of Medicine, show that computed tomography (CT) colonography - also known as virtual colonoscopy - can detect 90 percent of adenomas (noncancerous tumors that can progress to cancer) or colorectal cancers measuring 1 centimeter or more in diameter.
These results compare favorably with standard optical colonoscopy, "which misses roughly 8 to 10 percent" of lesions of this size, says Dr. Carl Jaffe, chief of the NCI Cancer Imaging Program's Diagnostic Imaging Branch.
Extra Copies of Chromosome Affects HER2 Test Results
Women with invasive breast cancer whose tumor cells have extra copies of chromosome 17, where the HER2 gene resides, are more likely to have borderline or "equivocal" results on HER2 testing, a team of Belgian researchers reports. In a study released September 15 in the Journal of Clinical Oncology (JCO), the researchers found that tumors with extra copies of chromosome 17 (a condition called polysomy 17) but not HER2 amplification - that is, extra copies of the HER2 gene - behaved like HER2-negative tumors.
The results of HER2 tests have significant implications for breast cancer patients, including whether they are candidates for the drug trastuzumab (Herceptin), which was specifically developed to treat HER2-positive disease.