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NIH-funded study uncovers range of molecular alterations in head and neck cancers, new potential drug targets; TCGA tumor genome sequencing analyses offer new insights into the effects of HPV and smoking
NCI Press Release
(Posted: 01/28/2015) - Investigators with The Cancer Genome Atlas (TCGA) Research Network have discovered genomic differences – with potentially important clinical implications – in head and neck cancers caused by infection with the human papillomavirus (HPV).

Mayo Clinic researchers report that a new breast cancer risk prediction model may be more accurate than current model
NCI Cancer Center News
(Posted: 01/27/2015) - A new breast cancer risk prediction model combining histologic features of biopsied breast tissue from women with benign breast disease and individual patient demographic information more accurately classified breast cancer risk than the current screening standard.

St. Jude researchers find that an inherited gene variation helps explain drug toxicity in patients of East Asian ancestry
NCI Cancer Center News
(Posted: 01/27/2015) - St. Jude researchers have identified an inherited variation in the NUDT15 gene that is strongly associated with a low tolerance for a drug that is a mainstay of pediatric ALL treatment.

UNC researchers pinpoint two genes that trigger severest form of ovarian cancer
NCI Cancer Center News
(Posted: 01/27/2015) - Researchers from the UNC School of Medicine create the first ever mouse model of ovarian clear cell carcinoma using data gleaned from the human cancer genome atlas.

Stanford study finds that care eliminates racial disparity in colon cancer survival rates
NCI Cancer Center News
(Posted: 01/27/2015) - A study by researchers at the Stanford University School of Medicine shows that more equitable delivery of evidence-based care can close a persistent racial disparity in colon cancer survival rates in the United States.

Image-guided biopsy for diagnosis of prostate cancer can increase detection of high-risk tumors
NCI News Note
(Posted: 01/27/2015) - In the largest prospective study to date of image-guided technology for identifying suspicious regions of the prostate to biopsy, researchers compared the ability of this technology to detect high-risk prostate cancer with that of the current standard of unguided prostate biopsy.

UCSD research shows that enzymes believed to promote cancer actually suppress tumors
NCI Cancer Center News
(Posted: 01/23/2015) - A team of scientists at the University of California, San Diego School of Medicine say enzymes long categorized as promoting cancer may, in fact, be tumor suppressors and that current clinical efforts to develop inhibitor-based drugs should instead focus on restoring the enzymes' activities.

Hopkins researchers find that a new cancer-fighting strategy would harden cells to prevent metastasis
NCI Cancer Center News
(Posted: 01/21/2015) - Existing cancer therapies are geared toward massacring tumor cells, but Johns Hopkins researchers propose a different strategy: subtly hardening cancer cells to prevent them from invading new areas of the body.

U Penn researchers find that mutated ATRX gene linked to brain tumors is a potential biomarker for rare adrenal tumors too
NCI Cancer Center News
(Posted: 01/21/2015) - For the first time, researchers at Penn's Abramson Cancer Center have found that a mutation in the ATRX may serve as a much-needed biomarker for the pheochromocytomas and paragangliomas that become malignant.

Dana-Farber study shows that vitamin D protects against colorectal cancer by boosting the immune system
NCI Cancer Center News
(Posted: 01/16/2015) - A new study by Dana-Farber Cancer Institute investigators demonstrates that vitamin D can protect some people with colorectal cancer by perking up the immune system's vigilance against tumor cells.

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