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Baylor scientists find that TopBP1 is a sweet spot for treatment in multiple cancers
NCI Cancer Center News
(Posted: 11/18/2014) - A compound called calcein may act to inhibit topoisomerase IIBeta-binding protein 1 (TopBP1), which enhances the growth of tumors, said researchers from Baylor College of Medicine.

Stanford researchers find that a noncoding RNA promotes pediatric bone cancer
NCI Cancer Center News
(Posted: 11/18/2014) - A new study in the Journal of Clinical Investigation indicates that a long non-coding RNA named Ewing sarcoma-associated transcript 1 contributes to the complex network of changes that occur in Ewing Sarcoma.

Northwestern U scientists develop genetic-based tool to detect circulating cancer cells in blood
NCi Cancer Center News
(Posted: 11/18/2014) - Northwestern University scientists have demonstrated a genetic-based approach that is able to detect live circulating tumor cells out of the complex matrix that is human blood.

Mayo researchers find that an investigational oral drug combo shows promise for newly diagnosed multiple myeloma
NCI Cancer Center News
(Posted: 11/18/2014) - The investigational drug ixazomib taken orally in combination with lenalidomide and dexamethasone shows promise in patients with newly diagnosed multiple myeloma.

Northwestern U researchers mouse study finds potential therapy for incurable pediatric brain tumor
NCI Cancer Center News
(Posted: 11/18/2014) - Northwestern University scientists have discovered a new potential drug therapy in mice for a rare, incurable pediatric brain tumor by targeting a genetic mutation found in children with the cancer.

MD Anderson researchers find that metabolic reprogramming by the p53 gene family leads to tumor regression
NCI Cancer Center News
(Posted: 11/18/2014) - Scientists have found that altering members of the p53 gene family, known as tumor suppressor genes, causes rapid regression of tumors that are deficient in or totally missing p53.

UCSF researchers find that nonsmokers in automobiles are exposed to significant secondhand smoke
NCI Cancer Center News
(Posted: 11/17/2014) - Nonsmokers sitting in an automobile with a smoker for one hour had markers of significantly increased levels of carcinogens and other toxins in their urine, indicating that secondhand smoke in motor vehicles poses a potentially major health risk.

Thomas Jefferson U researchers find that in mice normal cells can be protected by an anti-cancer drug
NCI Cancer Center News
(Posted: 11/17/2014) - An anti-cancer drug protects normal cells from radiation damage and increases the effectiveness of radiation therapy in prostate cancer mouse models.

Indiana U researchers identify key mechanism and potential target to prevent leukemia
NCI Cancer Center News
(Posted: 11/14/2014) - Researchers have identified two proteins that appear crucial to the development -- and patient relapse -- of acute myeloid leukemia.

Mass General researchers find that direct drug screening of patient biopsies could overcome resistance to targeted therapy
NCI Cancer Center News
(Posted: 11/14/2014) - A new screening platform using cells grown directly from tumor biopsy samples may lead to truly individualized treatment strategies that would get around the problem of treatment resistance, which limits the effectiveness of current targeted therapy drugs.

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