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UCSD researchers report on new mouse model that points to therapy for liver disease
NCI Cancer Center News
(Posted: 08/22/2014) - Development of effective new therapies for preventing or treating non-alcoholic fatty liver disease has been stymied by limited small animal models for the disease. In a paper published online in Cancer Cell, scientists at the University of California, San Diego School of Medicine describe a novel mouse model that closely resembles human NASH and use it to demonstrate that interference with a key inflammatory protein inhibits both the development of NASH and its progression to liver cancer.

Huntsman researchers outline possible next generation of chronic myeloid leukemia treatment
NCI Cancer Center News
(Posted: 08/21/2014) - A new study that identified mutated forms of a gene that encodes for mutated forms of CML.

Columbia University researchers find that severing nerves in mice may shrink stomach cancers
NCI Cancer Center News
(Posted: 08/21/2014) - Research from Columbia University Medical Center shows that nerves may play a critical role in stomach cancer growth and that blocking nerve signals using surgery or Botox (onabotulinumtoxinA) could be an effective treatment for the disease.

Rare kidney tumor provides insights on role of metabolic changes in cancer
NCI News Note
(Posted: 08/21/2014) - Researchers in The Cancer Genome Atlas (TCGA) Network have uncovered a number of new findings about the biology and development of a rare form of kidney cancer. They found that the disease – chromophobe renal cell carcinoma – stems in part from alterations in genes in the mitochondria, the cell’s energy supplier.

Massachussetts General-developed device monitors key step in development of tumor metastases
NCI Cancer Center News
(Posted: 08/19/2014) - A microfluidic device developed at Massachusetts General Hospital may help study key steps in the process by which cancer cells break off from a primary tumor to invade other tissues and form metastases.

NIH announces the launch of 3 integrated precision medicine trials; ALCHEMIST is for patients with certain types of early-stage lung cancer
NCI Press Release
(Posted: 08/18/2014) - The Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials, or ALCHEMIST, will identify early-stage lung cancer patients with tumors that harbor certain uncommon genetic changes and evaluate whether drug treatments targeted against those changes can lead to improved survival.
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Fred Hutchinson researchers report new findings related to patients with hard-to-treat head and neck cancers
NCI Cancer Center News
(Posted: 08/15/2014) - The scientists are using the technology in larger screens to look for more drug targets in head and neck, breast and pancreatic cancer.

UT San Antonio researchers find that NSAIDs may lower breast cancer recurrence rate in overweight and obese women
NCI Cancer Center News
(Posted: 08/15/2014) - Recurrence of hormone-related breast cancer was cut by half in overweight and obese women who regularly used aspirin or other nonsteroidal anti-inflammatory drugs.

Massey Cancer Center researchers identify protein that blocks benefits of vitamin A cancer therapy
NCI Cancer Center News
(Posted: 08/15/2014) - Researchers from Virginia Commonwealth University Massey Cancer Center demonstrated that a protein known as AEG-1 blocks the effects of retinoic acid in leukemia and liver cancer.

Roswell Park researchers identify priority targets for immunotherapy in epithelial ovarian cancer
NCI Cancer Center News
(Posted: 08/14/2014) - Researchers at Roswell Park Cancer Institute have found that the expression pattern of a unique class of tumor-associated antigens, known as the MAGE cancer-testis antigens, correlates with clinical outcome in epithelial ovarian cancer.

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