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Thomas Jefferson U researchers find that in mice normal cells can be protected by an anti-cancer drug
NCI Cancer Center News
(Posted: 11/17/2014) - An anti-cancer drug protects normal cells from radiation damage and increases the effectiveness of radiation therapy in prostate cancer mouse models.

Indiana U researchers identify key mechanism and potential target to prevent leukemia
NCI Cancer Center News
(Posted: 11/14/2014) - Researchers have identified two proteins that appear crucial to the development -- and patient relapse -- of acute myeloid leukemia.

Mass General researchers find that direct drug screening of patient biopsies could overcome resistance to targeted therapy
NCI Cancer Center News
(Posted: 11/14/2014) - A new screening platform using cells grown directly from tumor biopsy samples may lead to truly individualized treatment strategies that would get around the problem of treatment resistance, which limits the effectiveness of current targeted therapy drugs.

Stanford researchers determine that tumor suppressor also inhibits key property of stem cells
NCI Cancer Center News
(Posted: 11/14/2014) - A protein that plays a critical role in preventing the development of many types of human cancers has been shown also to inhibit a vital stem cell property called pluripotency.

MD Anderson researchers identify hedgehog signaling pathway for breast cancer
NCI Cancer Center News
(Posted: 11/14/2014) - Molecules called long non-coding RNAs -- lncRNAs -- have been implicated in breast cancer but exactly why they cause metastasis and tumor growth has been little understood... until now.

Thomas Jefferson U researchers find a novel cancer vaccine approach for brain tumors
NCI Cancer Center News
(Posted: 11/14/2014) - Researchers unravel the mechanisms behind a novel cancer vaccine for brain tumors, paving the way for further development

Dartmouth investigators determine that lung cancer screening with low-dose CT could be cost effective
NCI Cancer Center News
(Posted: 11/12/2014) - Dartmouth researchers say lung cancer screening in the National Lung Screening Trial meets a commonly accepted standard for cost effectiveness as reported in the Nov. 6 issue of the New England Journal of Medicine.

UT Southwestern study identifies cell of origin for large, disfiguring nerve tumors
NCI Cancer Center News
(Posted: 11/12/2014) - UT Southwestern Medical Center researchers have determined the specific type of cell that gives rise to large, disfiguring tumors called plexiform neurofibromas, a finding that could lead to new therapies for preventing growth of these tumors.

U of Colorado mouse study of next-gen melanoma drug, TAK-733
NCI Cancer Center News
(Posted: 11/12/2014) - A University of Colorado Cancer Center study published online this week in the journal Molecular Cancer Therapeutics reports anti-cancer activity in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733, a small molecule inhibitor of MEK1/2.

Roswell Park researchers find prognostic biomarker candidates for ovarian cancer
NCI Cancer Center News
(Posted: 11/12/2014) - Cancer researchers at Roswell Park Cancer Institute have identified two independent classes of novel candidate prognostic markers for ovarian cancer, advancing efforts to develop targeted therapies for the disease.

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