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Johns Hopkins scientists link gene to tamoxifen-resistant breast cancers
NCI Cancer Center News
(Posted: 11/25/2014) - After mining the genetic records of thousands of breast cancer patients, researchers from the Johns Hopkins Kimmel Cancer Center have identified a gene whose presence may explain why some breast cancers are resistant to tamoxifen, a widely used hormone treatment generally used after surgery, radiation and other chemotherapy.

U of Colorado researchers find that a one-two punch of drugs is better than either alone against colorectal cancer in mice
NCI Cancer Center News
(Posted: 11/25/2014) - Experimental anti-cancer agents PF-04691502 and PD-0325901 excel in lab tests against colorectal cancer models and enter phase 1 trial.

MD Anderson researchers find novel regulatory mechanism for cell division
NCI Cancer Center News
(Posted: 11/24/2014) - A protein kinase or enzyme known as PKM2 has proven to control cell division, potentially providing a molecular basis for tumor diagnosis and treatment.

Multiple biopsies are superior to a single biopsy in detecting cervical cancer precursors
NCI News Note
(Posted: 11/24/2014) - Performing multiple biopsies during a procedure known as colposcopy—visual inspection of the cervix—is more effective than performing only a single biopsy of the worst-appearing area for detecting cervical cancer precursors. This multiple biopsy approach may help to detect disease early and avoid repeated biopsies for women with initial negative findings, according to a new study by researchers at the National Cancer Institute and their colleagues.

Vanderbilt study finds more breast cancer patients opting for mastectomy
NCI Cancer Center News
(Posted: 11/21/2014) - Far more breast cancer patients are choosing to undergo mastectomy, including removal of both breasts, instead of choosing breast conservation surgery even when they have early stage disease that is confined to one breast, a Vanderbilt study shows.

MSK team makes key discovery in understanding immunotherapy's successes -- and its failures
NCI Cancer Center News
(Posted: 11/21/2014) - A collaborative team of leaders in the field of cancer immunology from Memorial Sloan Kettering Cancer Center has made a key discovery that advances the understanding of why some patients respond to ipilimumab, an immunotherapy drug, while others do not.

U of Chicago researchers find that STING pathway could be key to tumor immunity
NCI Cancer Center News
(Posted: 11/21/2014) - A protein complex known as STING plays a crucial role in detecting the presence of tumor cells and promoting an aggressive anti-tumor response by the body's innate immune system, according to two separate studies in Immunity.

Dana-Farber researchers and colleagues find that antiangiogenic treatment improves survival in animal model of ovarian cancer
NCI Cancer Center News
(Posted: 11/21/2014) - Coupling an antiangiogenic treatment with low-dose chemotherapy results in improved survival rates in an animal model of ovarian cancer.

Salk scientists deliver a promising one-two punch for lung cancer in mice
NCI Cancer Center News
(Posted: 11/21/2014) - Scientists at the Salk Institute have discovered a one-two punch for countering a common genetic mutation that often leads to drug-resistant cancers in mice.

Possible power behind 'master' gene for cancer discovered
NCI Cancer Center News
(Posted: 11/21/2014) - There are similarities between bean sprouts and human cancer. The same mechanisms that result in bigger bean sprouts also cause cancer metastasis and tumor development.

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