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New genetic risk variants identified in multiethnic analysis of prostate cancer
NCI News Note
(Posted: 09/14/2014) - Researchers have newly identified 23 common genetic variants -- one-letter changes in DNA known as single-nucleotide polymorphisms or SNPs -- that are associated with risk of prostate cancer. These results come from an analysis of more than 10 million SNPs in data pooled from studies that included over 43,000 men with prostate cancer and nearly 44,000 men without the disease. Study participants were from Australia, Ghana, Japan, the United Kingdom, and the United States and were of diverse ancestry.

St Jude genomic analysis reveals that a high-risk leukemia subtype becomes more common with age
NCI Cancer Center News
(Posted: 09/11/2014) - More than one-quarter of young adults with the most common form of acute lymphoblastic leukemia have a high-risk subtype with a poor prognosis and may benefit from drugs widely used to treat other types of leukemia that are more common in adults, according to multi-institutional research led by St. Jude Children’s Research Hospital investigators.

Dana-Farber researchers find that drug combination delays worsening of disease in women with recurrent ovarian cancer
NCI Cancer Center News
(Posted: 09/11/2014) - Researchers from the Susan F. Smith Center for Women’s Cancers at Dana-Farber report that for some women with recurrent ovarian cancer, a new drug combination has been found to stall the progression of the disease.

UNC researchers find new genetic target for a different kind of cancer drug
NCI Cancer Center News
(Posted: 09/09/2014) - Researchers from the UNC School of Medicine have discovered that the protein RBM4, a molecule crucial to the process of gene splicing, is drastically decreased in multiple forms of human cancer, including lung and breast cancers. The finding, published in the journal Cancer Cell, offers a new route toward therapies that can thwart the altered genetic pathways that allow cancer cells to proliferate and spread.

Stanford researchers find that UV light can turn gene into source of skin cancers
NCI Cancer Center News
(Posted: 09/08/2014) - A genetic mutation caused by ultraviolet light is likely the driving force behind millions of human skin cancers, according to researchers at the Stanford University School of Medicine.

UT Southwestern researchers find new gene mutations for Wilms Tumor
NCI Cancer Center News
(Posted: 09/08/2014) - Researchers at UT Southwestern Medical Center and the Gill Center for Cancer and Blood Disorders at Children’s Medical Center, Dallas, have made significant progress in defining new genetic causes of Wilms tumor, a type of kidney cancer found only in children.

Fred Hutchinson researchers find no link between wearing bras and breast cancer
NCI Cancer Center News
(Posted: 09/08/2014) - Study by researchers at the Fred Hutchinson Cancer Research Center found no evidence that wearing a bra increases a woman’s risk for breast cancer.

NCI study examines outcomes from surgery to prevent ovarian cancer
NCI News Note
(Posted: 09/08/2014) - A new study looked at women at high risk of ovarian cancer who had no clinical signs of the disease and who underwent risk-reducing salpingo-oophorectomy (RRSO). The study results showed cancer in the removed tissues of 2.6 percent (25 of 966) of the participants.

Hopkins researchers find that blood test for 'nicked' protein predicts prostate cancer treatment response
NCI Cancer Center News
(Posted: 09/04/2014) - Prostate cancer patients whose tumors contain a shortened protein called AR-V7, which can be detected in the blood, are less likely to respond to two widely used drugs for metastatic prostate cancer, according to results of a study led by researchers at the Johns Hopkins Kimmel Cancer Center.

Hopkins researchers find that if prepped by tumor cells, lymphatic cells can encourage breast cancer cells to spread
NCI Cancer Center News
(Posted: 09/03/2014) - Breast cancer cells can lay the groundwork for their own spread throughout the body by coaxing cells within lymphatic vessels to send out tumor-welcoming signals.

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