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St. Jude researchers find that improved risk identification will aid fertility preservation in young male cancer patients
NCI Cancer Center News
(Posted: 09/17/2014) - St. Jude Children’s Research Hospital study has identified the cumulative dose of a widely used class of chemotherapy drugs that leaves young male cancer patients at risk for impaired sperm production as adults.

UCSD researchers find that cancer and the immune system are a double-edged sword
NCI Cancer Center News
(Posted: 09/16/2014) - During cancer development, tumor cells decorate their surfaces with sugar compounds called glycans that are different from those found on normal, healthy cells.

New knowledge of genes driving bladder cancer points to targeted treatments
NCI Cancer Center News
(Posted: 09/15/2014) - Dan Theodorescu, M.D., Ph.D., director of the University of Colorado Cancer Center, and colleagues from the National Cancer Institute show genes commonly mutated in bladder cancer, implying at least two.

U of Colorado researchers find a new drug could block gene driving cancer growth
NCI Cancer Center News
(Posted: 09/15/2014) - U of Colorado researchers find a new drug that could block a gene driving cancer activation, and could in principle be used to discover drugs aimed at other proteins driving human disease as well.

New genetic risk variants identified in multiethnic analysis of prostate cancer
NCI News Note
(Posted: 09/14/2014) - Researchers have newly identified 23 common genetic variants -- one-letter changes in DNA known as single-nucleotide polymorphisms or SNPs -- that are associated with risk of prostate cancer. These results come from an analysis of more than 10 million SNPs in data pooled from studies that included over 43,000 men with prostate cancer and nearly 44,000 men without the disease. Study participants were from Australia, Ghana, Japan, the United Kingdom, and the United States and were of diverse ancestry.

St Jude genomic analysis reveals that a high-risk leukemia subtype becomes more common with age
NCI Cancer Center News
(Posted: 09/11/2014) - More than one-quarter of young adults with the most common form of acute lymphoblastic leukemia have a high-risk subtype with a poor prognosis and may benefit from drugs widely used to treat other types of leukemia that are more common in adults, according to multi-institutional research led by St. Jude Children’s Research Hospital investigators.

Dana-Farber researchers find that drug combination delays worsening of disease in women with recurrent ovarian cancer
NCI Cancer Center News
(Posted: 09/11/2014) - Researchers from the Susan F. Smith Center for Women’s Cancers at Dana-Farber report that for some women with recurrent ovarian cancer, a new drug combination has been found to stall the progression of the disease.

UNC researchers find new genetic target for a different kind of cancer drug
NCI Cancer Center News
(Posted: 09/09/2014) - Researchers from the UNC School of Medicine have discovered that the protein RBM4, a molecule crucial to the process of gene splicing, is drastically decreased in multiple forms of human cancer, including lung and breast cancers. The finding, published in the journal Cancer Cell, offers a new route toward therapies that can thwart the altered genetic pathways that allow cancer cells to proliferate and spread.

Stanford researchers find that UV light can turn gene into source of skin cancers
NCI Cancer Center News
(Posted: 09/08/2014) - A genetic mutation caused by ultraviolet light is likely the driving force behind millions of human skin cancers, according to researchers at the Stanford University School of Medicine.

UT Southwestern researchers find new gene mutations for Wilms Tumor
NCI Cancer Center News
(Posted: 09/08/2014) - Researchers at UT Southwestern Medical Center and the Gill Center for Cancer and Blood Disorders at Children’s Medical Center, Dallas, have made significant progress in defining new genetic causes of Wilms tumor, a type of kidney cancer found only in children.

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