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Stanford researchers determine that tumor suppressor also inhibits key property of stem cells
NCI Cancer Center News
(Posted: 11/14/2014) - A protein that plays a critical role in preventing the development of many types of human cancers has been shown also to inhibit a vital stem cell property called pluripotency.

MD Anderson researchers identify hedgehog signaling pathway for breast cancer
NCI Cancer Center News
(Posted: 11/14/2014) - Molecules called long non-coding RNAs -- lncRNAs -- have been implicated in breast cancer but exactly why they cause metastasis and tumor growth has been little understood... until now.

Thomas Jefferson U researchers find a novel cancer vaccine approach for brain tumors
NCI Cancer Center News
(Posted: 11/14/2014) - Researchers unravel the mechanisms behind a novel cancer vaccine for brain tumors, paving the way for further development

Dartmouth investigators determine that lung cancer screening with low-dose CT could be cost effective
NCI Cancer Center News
(Posted: 11/12/2014) - Dartmouth researchers say lung cancer screening in the National Lung Screening Trial meets a commonly accepted standard for cost effectiveness as reported in the Nov. 6 issue of the New England Journal of Medicine.

UT Southwestern study identifies cell of origin for large, disfiguring nerve tumors
NCI Cancer Center News
(Posted: 11/12/2014) - UT Southwestern Medical Center researchers have determined the specific type of cell that gives rise to large, disfiguring tumors called plexiform neurofibromas, a finding that could lead to new therapies for preventing growth of these tumors.

U of Colorado mouse study of next-gen melanoma drug, TAK-733
NCI Cancer Center News
(Posted: 11/12/2014) - A University of Colorado Cancer Center study published online this week in the journal Molecular Cancer Therapeutics reports anti-cancer activity in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733, a small molecule inhibitor of MEK1/2.

Roswell Park researchers find prognostic biomarker candidates for ovarian cancer
NCI Cancer Center News
(Posted: 11/12/2014) - Cancer researchers at Roswell Park Cancer Institute have identified two independent classes of novel candidate prognostic markers for ovarian cancer, advancing efforts to develop targeted therapies for the disease.

U Penn researchers classify gene mutations in a children's cancer that may point to improved treatments
NCI Cancer Center News
(Posted: 11/12/2014) - Oncology researchers studying gene mutations in the childhood cancer neuroblastoma are refining their diagnostic tools to predict which patients are more likely to respond to drugs called ALK inhibitors that target such mutations.

Recipients of Cancer Clinical Investigator Team Leadership Awards Announced
NCI News Note
(Posted: 11/12/2014) - NCI’s Cancer Clinical Investigator Team Leadership Awards recognize and support outstanding mid-career clinical investigators at NCI-Designated Cancer Centers who participate extensively in NCI-funded collaborative clinical trials and whose leadership, participation, and activities promote a culture of successful clinical research. This year, 11 investigators nationwide have received the award.

Dana-Farber researchers take new approach to stop 'most wanted' cancer protein
NCI Cancer Center News
(Posted: 11/10/2014) - Researchers at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center have found a way to defeat one of the most tantalizing yet elusive target proteins in cancer cells – employing a strategy that turns the protein’s own molecular machinations against it. In a study published online by the journal Cell, the scientists used a specially crafted compound to disrupt the protein’s ability to rev up its own production and that of other proteins involved in tumor cell growth.

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