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The benefits of looking across many cancer genomes: A perspective
NCI Perspective
(Posted: 09/27/2013, Updated: 08/12/2014) - Cancer is not a single entity, but rather, it is more than one hundred complex and distinct diseases, with most cancer types demanding a unique treatment strategy. TCGA researchers have developed a formal project for a cross tumor analysis, called Pan-Cancer. Its goal is to assemble TCGA’s wealth of data across tumor types, analyze and interpret those data, and finally, make both the analyses and the data freely available.

Duke research delves into editing HPV's genes to kill cervical cancer cells
NCI Cancer Center News
(Posted: 08/11/2014) - Using the genome editing tool known as CRISPR, Duke University researchers were able to selectively destroy two viral genes responsible for the growth and survival of cervical carcinoma cells, causing the cancer cells to self-destruct.

MIT researchers find a new way to model cancer using mice
NCI Cancer Center News
(Posted: 08/07/2014) - One way to discover the role of the mutations is to breed a strain of mice that carry the genetic flaw — but breeding such mice is an expensive, time-consuming process. Now, MIT researchers have found an alternative.

University of Michigan researchers find that gut microbiome analysis improved noninvasive colorectal cancer screening
NCI Cancer Center News
(Posted: 08/07/2014) - Analysis of the gut microbiome more successfully distinguished healthy individuals from those with precancerous adenomatous polyps and those with invasive colorectal cancer compared with assessment of clinical risk factors and fecal occult blood testing.

Stanford researchers find that rare developmental disorder is linked to tumor-suppressing protein
NCI Cancer Center News
(Posted: 08/04/2014) - Researchers have revealed a new insight into CHARGE syndrome, a rare developmental disorder.

MIT and Whitehead researchers find that a faster heat-shock factor supports reprogramming of normal cells to enable tumor growth and metastasis
NCI Cancer Center News
(Posted: 08/04/2014) - Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat-Shock Factor 1 (HSF1) can also turn neighboring cells in their environment into co-conspirators that support malignant progression and metastasis.

UCSD researchers find that chili peppers may inhibit gut tumors in mice
NCI Cancer Center News
(Posted: 08/04/2014) - Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin – the active ingredient in chili peppers – produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.

Hopkins researchers find that blood and saliva tests help predict return of HPV-linked oral cancers
NCI Cancer Center News
(Posted: 08/04/2014) - Johns Hopkins scientists have developed blood and saliva tests that help accurately predict recurrences of HPV-linked oral cancers in a substantial number of patients.

UCSD researchers find that tumor suppressor mutations alone don't explain deadly cancer
NCI Cancer Center News
(Posted: 08/04/2014) - Although mutations in a gene dubbed 'the guardian of the genome' are widely recognized as being associated with more aggressive forms of cancer, researchers have found evidence suggesting that the deleterious health effects of the mutated gene may in large part be due to other genetic abnormalities, at least in squamous cell head and neck cancers.

Dana-Farber study finds new genetic risk markers in pancreatic cancer
NCI Cancer Center News
(Posted: 08/04/2014) - A large DNA analysis of people with and without pancreatic cancer has identified several new genetic markers that signal increased risk of developing the highly lethal disease.

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