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Researchers at Broad Institute and MIT engineer "Cas9" animal models to study disease and inform drug discovery
NCI Cancer Center News
(Posted: 09/26/2014) - Researchers from the Broad Institute and Massachusetts Institute of Technology have created a new mouse model to simplify application of the CRISPR-Cas9 system for in vivo genome editing experiments.

Dana-Farber researchers find that a novel compound prevents metastasis of multiple myeloma in mouse studies
NCI Cancer Center News
(Posted: 09/26/2014) - In a significant advance against the problem of cancer metastasis, Dana-Farber Cancer Institute scientists have shown that a specially developed compound can impede multiple myeloma from spreading to the bones in mice. The findings, published in the Sept. 25 issue of Cell Reports, suggest the technique can protect human patients, as well, from one of the most deadly aspects of cancer.

USC researchers find that a single genetic change can cause cancerous tumors in a child’s eyes
NCI Cancer Center News
(Posted: 09/25/2014) - Researchers have answered the long-standing question of why mutations to a particular gene primarily cause tumors of the retina and not of other cell types. Led by experts at the USC Eye Institute, the study could reveal new cellular signaling pathways relevant to retinal development, cancer development and the development of novel therapies.

Vanderbilt study questions accuracy of lung cancer screens in some geographic regions
NCI Cancer Center News
(Posted: 09/24/2014) - A new analysis of published studies found that FDG-PET technology is less accurate in diagnosing lung cancer versus benign disease in regions where infections like histoplasmosis or tuberculosis are common.

NIH exceptional responders to cancer therapy study launched
NCI Press Release
(Posted: 09/24/2014) - The Exceptional Responders Initiative, a study to investigate the molecular factors of tumors associated with exceptional treatment responses of cancer patients to drug therapies, was launched today by NCI. Scientists will attempt to identify the molecular features of tumors that predict whether or not a particular drug or class of drugs will be beneficial.
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Massachusetts General mouse study reveals gene expression patterns in pancreatic CTCs
NCI Cancer Center News
(Posted: 09/23/2014) - Analysis of circulating tumor cells (CTCs) in a mouse model of pancreatic cancer identified distinct patterns of gene expression in several groups of CTCs, including significant differences from the primary tumor that may contribute to the ability to generate metastases.

Dana-Farber researchers articulate the fine line between breast cancer and normal tissues
NCI Cancer Center News
(Posted: 09/23/2014) - Up to 40 percent of patients undergoing breast cancer surgery require additional operations because surgeons may fail to remove all the cancerous tissue in the initial operation.

U of Pittsburgh researchers potentially find a better way to track emerging cell therapies using MRIs
NCI Cancer Center News
(Posted: 09/22/2014) - Researchers describe the first human tests of using a perfluorocarbon (PFC) tracer in combination with non-invasive magnetic resonance imaging (MRI) to track therapeutic immune cells injected into patients with colorectal cancer.

UPenn researchers find that in mouse study, exercise added to chemo shrinks tumors faster
NCI Cancer Center News
(Posted: 09/22/2014) - Adding exercise to a regimen of chemotherapy shrinks tumors more than chemotherapy alone, according to a study with mice.

Stanford researchers create evolved protein in mice that may stop cancer from spreading
NCI Cancer Center News
(Posted: 09/22/2014) - Stanford researchers have created a decoy protein designed to interrupt the signaling pathway that triggers the breakaway of cancerous cells; in other words the signal that initiates metastasis.

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