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MIT researchers undertake fast modeling of cancer mutations in mice
NCI Cancer Center News
(Posted: 10/23/2014) - MIT researchers have developed a new way to model the effects of genetic mutations in mice. Their approach, based on the genome-editing technique known as CRISPR, is much faster than existing strategies, which require genetically engineering mice that carry the cancerous mutations.

U of Chicago researchers find that new anti-cancer drug shows few side effects in mice
NCI Cancer Center News
(Posted: 10/23/2014) - A new drug, known as OTS964, may eradicate aggressive human lung cancers transplanted into mice, according to a report in Science Translational Medicine.

Dana-Farber and other researchers find that silencing the speech gene FOXP2 causes breast cancer cells to metastasize
NCI Cancer Center News
(Posted: 10/23/2014) - A research team led by investigators at Beth Israel Deaconess Medical Center has identified an unexpected link between a transcription factor known to regulate speech and language development and metastatic colonization of breast cancer.

TCGA study improves understanding of genetic drivers of thyroid cancer
NCI News Note
(Posted: 10/23/2014) - A comprehensive analysis of the genomes of nearly 500 papillary thyroid carcinomas (PTC) – the most common form of thyroid cancer – has provided new insights into the roles of frequently mutated cancer genes and other genomic alterations that drive disease development, information that may help improve diagnosis and treatment. Findings confirmed that PTCs are driven primarily by mutations in one of two cancer-associated genes: BRAF (and a particular BRAF mutation noted as V600E ) or RAS.

UNC scientists discover hidden subpopulation of melanoma cells
NCI Cancer Center News
(Posted: 10/22/2014) - UNC researchers discover a subpopulation of melanoma cancer cells in blood vessels of tumors.

Mayo and NCI researchers find that trastuzumab continues to show life for HER2-positve early stage breast cancer
NCI Cancer Center News
(Posted: 10/21/2014) - After following breast cancer patients for an average of eight-plus years, researchers say that adding trastuzumab (Herceptin) to chemotherapy significantly improved the overall and disease-free survival of women with early stage HER2-positive breast cancer.

UCSF researchers find a genetic variant that may protect some Latina women from breast cancer
NCI Cancer Center News
(Posted: 10/20/2014) - An international research collaboration led by UC San Francisco researchers has identified a genetic variant common in Latina women that may protect against breast cancer.

University of Arizona researchers find that a good diet before diagnosis is linked with lower mortality among ovarian cancer survivors
NCI Cancer Center News
(Posted: 10/20/2014) - Prediagnosis diet quality was associated with mortality and may have a protective effect after ovarian cancer, according to a new study published October 14 in the JNCI: Journal of the National Cancer Institute.

Washington U researchers find that many older people have mutations linked to leukemia, lymphoma in their blood cells
NCI Cancer Center News
(Posted: 10/20/2014) - At least 2 percent of people over age 40 and 5 percent of people over 70 have mutations linked to leukemia and lymphoma in their blood cells, according to new research at Washington University School of Medicine in St. Louis.

MD Anderson researchers compare treatments, survival benefits for early-stage lung cancer
NCI Cancer Center News
(Posted: 10/20/2014)

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