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University of Pittsburgh Medical Center researchers find that media literacy may trump anti-smoking lessons
NCI Cancer Center News
(Posted: 01/15/2014) - To keep teenagers from starting to smoke, media literacy programs work better than traditional anti-smoking lessons, a new study suggests.

Johns Hopkins scientists find that a small molecule shows promise as anti-cancer therapy
NCI Cancer Center News
(Posted: 01/14/2014) - Johns Hopkins scientists say a previously known but little studied chemical compound targets and shuts down a common cancer process.

Dana-Farber study of multiple myeloma uncovers genetic diversity within tumors
NCI Cancer Center News
(Posted: 01/14/2014) - The most comprehensive genetic study to date of the blood cancer multiple myeloma has revealed that the genetic landscape of the disease may be more complicated than previously thought.

MD Anderson researchers find that a more targeted form of radiation improves survival in patients with head, neck cancers
NCI Cancer Center News
(Posted: 01/14/2014) - Researchers on the population-based retrospective study used the Surveillance, Epidemiology and End Results (SEER) Medicare database, compiled by the National Cancer Institute, to identify 3,172 patients treated for head and neck cancer between 1999 -- 2007 who received either conventional radiation therapy or IMRT.

Dana-Farber scientists identify mutated gene that could improve treatment for rare brain tumor type
NCI Cancer Center News
(Posted: 01/13/2014) - The discovery of a mutated gene that causes a type of tenacious, benign brain tumor may make it possible to attack the tumor with targeted drugs already in use for other kinds of tumors.

Penn Medicine study finds two behavioral interventions help cancer patients struggling with sleep issues
NCI Cancer Center News
(Posted: 01/13/2014) - Cancer patients who are struggling with sleep troubles, due in part to pain or side effects of treatment, can count on two behavioral interventions for relief. The interventions include cognitive behavioral therapy for insomnia (CBT-I) and mindfulness-based stress reduction (MBSR).

Fred Hutchinson Cancer Institute develops nomogram to determine individualized estimates of screen-detected prostate cancer overdiagnosis
NCI Cancer Center News
(Posted: 01/13/2014) - Fred Hutchinson Cancer Institute researchers have developed a nomogram that incorporates age, Gleason score, and prostate-specific antigen (PSA) level at diagnosis, so that an individual's risk that a screen-detected prostate cancer has been overdiagnosed can be estimated.

Researchers develop tool to determine individual risk of prostate cancer overdiagnosis
NCI Cancer Center News
(Posted: 01/10/2014) - Researchers at Fred Hutchinson Cancer Research Center and the University of Washington have developed a personalized tool that can predict the likelihood of prostate cancer overdiagnosis. They announced their findings this week in the online issue of the Journal of the National Cancer Institute. The researchers created a nomogram, a graphical calculating device, that incorporates a patient’s age, prostate-specific antigen (PSA) level and Gleason score – which grades prostate cancer tissue based on how it looks under a microscope – to determine the likelihood that screening-detected prostate cancer has been overdiagnosed.

Antipsychotic drug exhibits cancer-fighting properties
NCI Cancer Center News
(Posted: 01/10/2014) - In a prime example of finding new uses for older drugs, studies in zebrafish show that a 50-year-old antipsychotic medication called perphenazine can actively combat the cells of a difficult-to-treat form of acute lymphoblastic leukemia (ALL). The drug works by turning on a cancer-suppressing enzyme called PP2A and causing malignant tumor cells to self-destruct.The findings, by a team from the Dana-Farber/Boston Children's Cancer and Blood Disorders Center, the Dana-Farber Cancer Institute, and Brigham and Women's Hospital suggest that developing medications that activate PP2A, while avoiding perphenazine's psychotropic effects, could help clinicians make much-needed headway against T-cell ALL, and perhaps other tumors as well.

Study shows promise for preventing therapy resistance in tumor cells
NCI Cancer Center News
(Posted: 01/10/2014) - A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par-4, another potent tumor suppressor protein that induces cell death in cancer cells. This finding may help researchers decipher how to inhibit the growth of tumors that have become resistant to other treatments. The University of Kentucky is home to the UK Markey Cancer Center.

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