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Study in mice shows that an aggressive type of breast cancer is linked to an inflammatory protein
NCI News Note
(Posted: 04/14/2014) - Aberrant expression of an inflammatory protein, nitric oxide synthase 2 (NOS2), may enhance the progression and metastasis of an aggressive and less common form of breast cancer, known as the estrogen receptor-negative type of disease.

An Open Letter to the Cancer Community Regarding Community Clinical Trials
(Posted: 04/11/2014) - The National Cancer Institute (NCI) is in the process of combining its two community-based research networks to create a single network that builds on the strengths of the Community Clinical Oncology Program/Minority-Based Community Clinical Oncology Program (CCOPs) and the NCI Community Cancer Centers Program (NCCCP).

Duke researchers find that cancer’s thirst for copper can be targeted
NCI Cancer Center News
(Posted: 04/10/2014) - Drugs used to block copper absorption for a rare genetic condition may find an additional use as a treatment for certain types of cancer, researchers at Duke Medicine report.

UC Davis researchers find that a double-headed motor protein offers new targets in cancer treatment
NCI Cancer Center News
(Posted: 04/09/2014) - The structure of a key part of the machinery that allows cells to divide has been identified by researchers at the University of California, Davis, opening new possibilities for throwing a wrench in the machine and blocking runaway cell division in cancer.

St. Jude study finds that tumor suppressor gene TP53 is mutated in 90 percent of most common childhood bone tumor
NCI Cancer Center News
(Posted: 04/07/2014) - St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project finds TP53 gene is altered in nearly all osteosarcomas and results help explain how tumors withstand radiation therapy.

Stanford study finds that blood test could provide rapid, accurate method of detecting solid cancers
NCI Cancer Center News
(Posted: 04/07/2014) - A blood sample may one day be enough to diagnose many types of solid cancers, or to monitor the amount of solid cancer in a patient's body, a new study shows.

Dana-Farber scientists find potential drug targets in deadly pediatric brain tumors
NCI Cancer Center News
(Posted: 04/07/2014) - Researchers studying a rare, always fatal brain tumor in children have found several molecular alterations that drive the cancer.

St. Jude study of gene sequencing discovers mutations tied to deadly brain tumors in infants
NCI Cancer Center News
(Posted: 04/07/2014) - St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project offers new leads to improved outcomes for children with high-grade glioma brain tumors, particularly youngest patients.

NCI intramural research highlighted at 2014 AACR meeting
NCI Perspective Article
(Posted: 04/07/2014) - This year’s American Association for Cancer Research meeting featured plenary talks by two NCI scientists, Steven Rosenberg, M.D., and Louis Staudt, M.D., Ph.D., that highlighted the challenges in developing varied and potentially synergistic treatments for aggressive forms of cancer. Each researcher has been focusing primarily on a particularly difficult to treat cancer (melanoma and lymphoma, respectively) for many decades, and their presentations highlight the diligence and tenacity needed to come to a better understanding of the cancer process and to find effective agents to target the diseases they study.

Statement on Forthcoming Changes in NCI's Clinical Trials Programs
(Posted: 04/04/2014) - Clinical trials are pivotal elements in the conversion of scientific discoveries into practical means to prevent and treat cancers.
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