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Where HIV genetic information is inserted into host DNA is linked to clonal growth and persistence of infected cells
NCI News Note
(Posted: 06/26/2014) - Based on an analysis of blood cells from five HIV-infected individuals, NCI researchers have identified more than 2,400 HIV DNA insertion sites. Analysis of these sites showed that there is extensive clonal expansion (growth) of HIV infected cells.

Dartmouth researchers find that youth indoor tanning increases early risk of skin cancer
NCI Cancer Center News
(Posted: 06/24/2014) - Dartmouth researchers have found that early exposure to the ultraviolet radiation lamps used for indoor tanning is related to an increased risk of developing basal cell carcinomas at a young age.

UAB research points to possible therapy because brain tumor cells move, damage tissue
NCI Cancer Center News
(Posted: 06/23/2014) - This study provides insight into the mechanisms of how glioma cells spread throughout the brain as a devastating form of brain cancer, and potentially offers a tantalizing opportunity for therapy.

Huntsman researchers use mouse model in lung cancer
NCI Cancer Center News
(Posted: 06/20/2014) - Huntsman Cancer Institute investigators report that misregulation of two genes, sox2 and lkb1, drives squamous cell lung cancer in mice.

U of Chicago researchers develop new tool that predicts financial pain for cancer patients
NCI Cancer Center News
(Posted: 06/20/2014) - Researchers have found that cancer care has a new side effect. Along with the distress that comes with a cancer diagnosis and the discomforts of treatment, more patients now have to deal with "financial toxicity".

UCLA scientists discover how adult stem cell regulation contributes to lung cancer
NCI Cancer Center News
(Posted: 06/20/2014) - Stem cells that repair injuries in lung airways are regulated by molecules called reactive oxygen species (ROS). Increase in ROS levels trigger stem cells to divide and repair the airways; ROS then returns to the healthy baseline level.

Dana-Farber scientists identify additional challenges in KRAS-driven cancers
NCI Cancer Center News
(Posted: 06/20/2014) - Scientists have redoubled efforts to disable the mutated cancer gene KRAS, which confers an especially poor prognosis and has proved extraordinarily difficult to target.

Hopkins researchers find that a vaccine can reprogram pancreatic cancers to respond to immunotherapy
NCI Cancer Center News
(Posted: 06/19/2014) - Researchers at the Johns Hopkins Kimmel Cancer Center have developed and tested a vaccine that triggered the growth of immune cell nodules within pancreatic tumors, essentially reprogramming these intractable cancers and potentially making them vulnerable to immune-based therapies.

Study finds stronger nicotine dependency associated with higher risk of lung cancer
NCI News Note
(Posted: 06/19/2014) - NCI headed study finds people who are highly addicted to nicotine -- those who smoke their first cigarette within five minutes after awakening -- are at higher risk of developing lung cancer than those who wait for an hour or more to smoke.

Memorial Sloan-Kettering study compares survival for treatments of uncommon eye cancer
NCI Cancer Center News
(Posted: 06/18/2014) - In patients with advanced uveal melanoma, treatment with the agent selumetinib, compared with chemotherapy, resulted in an improved cancer progression-free survival time and tumor response rate, but no improvement in overall survival, according to a study in the June 18 issue of JAMA.

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