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Diabetes identified as risk factor for liver cancer across ethnic groups
NCI Cancer Center News
(Posted: 12/09/2013) - Diabetes was associated with an increased risk for developing a type of liver cancer called hepatocellular carcinoma, and this association was highest for Latinos, followed by Hawaiians, African-Americans, and Japanese-Americans, according to results presented by researchers from the Keck School of Medicine of the University of Southern California (home of the USC Norris Comprehensive Cancer Center) at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9.

Economic factors may affect getting guideline-recommended breast cancer treatment
NCI Cancer Center News
(Posted: 12/09/2013) - Women with interruptions in health insurance coverage or with low income levels had a significantly increased likelihood of failing to receive breast cancer care that is in concordance with recommended treatment guidelines, according to results presented at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9. Women with a break in their insurance coverage had a 3.5-fold higher likelihood of nonconcordance with National Comprehensive Cancer Network (NCCN) guidelines for radiation therapy and chemotherapy compared with women with uninterrupted coverage, according to a study from the Fred Hutchinson Cancer Research Center.

Novel method could help bring cancer biomarkers to clinic
NCI Cancer Center News
(Posted: 12/09/2013) - An international team of scientists led by a Fred Hutchinson Cancer Research Center cancer proteomics expert has demonstrated the feasibility of large-scale, standardized protein measurements, which are necessary for validation of disease biomarkers and drug targets. The study, published Dec. 8 online in the journal Nature Methods, shows that the scientists' targeted protein-detection approach has the potential to systematically and reliably measure the entire human repertoire of proteins, known as the proteome.

Novel drug regimen can improve stem cell transplantation outcomes
NCI Cancer Center News
(Posted: 12/09/2013) - Adding bortezomib (Velcade) to standard preventive therapy for graft-versus-host-disease (GVHD) results in improved outcomes for patients receiving stem cell transplants from mismatched and unrelated donors, according to researchers from Dana-Farber Cancer Institute. In a new phase 2 trial, patients treated with bortezomib had lower rates of severe acute GVHD and treatment-related mortality, and experienced better one-year overall survival than has been seen historically with such patients receiving standard preventive therapy, the investigators reported at the American Society of Hematology annual meeting.

Potential biological factor contributing to racial disparities in prostate cancer
NCI Cancer Center News
(Posted: 12/09/2013) - Researchers from the Medical University of South Carolina (home of the Hollings Cancer Center) have uncovered a potential biological factor that may contribute to disparities in prostate cancer incidence and mortality between African-American and non-Hispanic white men in the United States, according to results presented at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9. In the United States, African-American men are 1.5 times more likely to develop prostate cancer and more than twice as likely to die from the disease compared with non-Hispanic white men.

New studies demonstrate that modified T cells are effective in treating blood-borne cancers
NCI News Note
(Posted: 12/09/2013) - At the 2013 American Society of Hematology meeting in Dec. 2013, James Kochenderfer, M.D., NCI, presented findings from two clinical trials evaluating the use of genetically modified immune system T cells as cancer therapy. These reports represent important advances in the understanding of gene therapy for treatment of advanced blood-borne cancers.

Unlocking how brain cancer cells hide from drugs
NCI Cancer Center News
(Posted: 12/06/2013) - Researchers from UCLA’s Jonsson Comprehensive Cancer Center (JCCC) have discovered a biological mechanism that allows brain tumor cells to escape from the drugs designed to target them, resulting in drug resistance. The study was published in the December 5, 2013 online issue of Science.

Cancer mutation likely trigger of scleroderma
NCI Cancer Center News
(Posted: 12/06/2013) - Johns Hopkins scientists have found evidence that cancer triggers the autoimmune disease scleroderma, which causes thickening and hardening of the skin and widespread organ damage. A report on the discovery, published in the Dec. 5 issue of Science, also suggests that a normal immune system is critical for preventing the development of common types of cancer. Johns Hopkins is home to the Sidney Kimmel Cancer Center.

Fred Hutchinson Cancer Research Center study examines predicting ovarian cancer by counting tumor-attacking immune cells
NCI Cancer Center News
(Posted: 12/05/2013) - Scientists at Fred Hutchinson Cancer Research Center have developed a new method for counting a special class of cancer-fighting cells – called tumor-infiltrating T lymphocytes, or TILs – reliably, quickly and cheaply in patients with early stage and advanced ovarian cancer.

3-D mammography increases cancer detection and reduces call-back rates
NCI Cancer Center News
(Posted: 12/04/2013) - Compared to traditional mammography, 3D mammography—known as digital breast tomosynthesis—found 22 percent more breast cancers and led to fewer call backs in a large screening study at the Hospital of the University of Pennsylvania (HUP), researchers reported at the annual meeting of the Radiological Society of North America (RSNA). The University of Pennsylvania is home to the Abramson Cancer Center.

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