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NCI establishes Genomic Data Commons to facilitate identification of molecular subtypes of cancer and potential drug targets
NCI News Note
(Posted: 12/02/2014) - NCI is establishing the Genomic Data Commons to store, analyze and distribute cancer genomics data generated by NCI and other research organizations. The GDC will provide an interactive system for researchers to access data, with the goal of advancing the molecular diagnosis of cancer and suggest potential therapeutic targets based on genomic information.

UCLA scientists discover why patients respond to a melanoma drug
NCI Cancer Center News
(Posted: 12/01/2014) - UCLA scientists studied why some patients with aggressive melanoma respond while others do not to the immunotherapy drug pembrolizumab.

Hunstman researchers find that a rare cancer exposes possible route to new treatments
NCI Cancer Center News
(Posted: 12/01/2014) - Researchers from Huntsman Cancer Institute at the University of Utah discovered the unusual role of lactate in the metabolism of alveolar soft part sarcoma, a rare, aggressive cancer that primarily affects adolescents and young adults.

Thomas Jefferson U researchers find that HIV drug blocks bone metastases in prostate cancer
NCI Cancer Center News
(Posted: 12/01/2014) - The receptor CCR5, targeted by HIV drugs, is also key in driving prostate cancer metastases, suggesting that blocking this molecule could slow prostate cancer spread.

Washington University researchers conduct small clinical trial of a breast cancer vaccine
NCI Cancer Center News
(Posted: 12/01/2014) - A breast cancer vaccine designed by researchers at Washington University School of Medicine in St. Louis was found to be safe in patients with metastatic breast cancer.

St. Jude researchers find that survivors of childhood eye cancer experience normal cognitive functioning as adults
NCI Cancer Center News
(Posted: 11/25/2014) - St. Jude Children’s Research Hospital study found adults diagnosed with retinoblastoma as infants often performed better on tasks than survivors diagnosed at an older age.

Johns Hopkins scientists link gene to tamoxifen-resistant breast cancers
NCI Cancer Center News
(Posted: 11/25/2014) - After mining the genetic records of thousands of breast cancer patients, researchers from the Johns Hopkins Kimmel Cancer Center have identified a gene whose presence may explain why some breast cancers are resistant to tamoxifen, a widely used hormone treatment generally used after surgery, radiation and other chemotherapy.

U of Colorado researchers find that a one-two punch of drugs is better than either alone against colorectal cancer in mice
NCI Cancer Center News
(Posted: 11/25/2014) - Experimental anti-cancer agents PF-04691502 and PD-0325901 excel in lab tests against colorectal cancer models and enter phase 1 trial.

MD Anderson researchers find novel regulatory mechanism for cell division
NCI Cancer Center News
(Posted: 11/24/2014) - A protein kinase or enzyme known as PKM2 has proven to control cell division, potentially providing a molecular basis for tumor diagnosis and treatment.

Multiple biopsies are superior to a single biopsy in detecting cervical cancer precursors
NCI News Note
(Posted: 11/24/2014) - Performing multiple biopsies during a procedure known as colposcopy—visual inspection of the cervix—is more effective than performing only a single biopsy of the worst-appearing area for detecting cervical cancer precursors. This multiple biopsy approach may help to detect disease early and avoid repeated biopsies for women with initial negative findings, according to a new study by researchers at the National Cancer Institute and their colleagues.

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