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Avon Foundation for Women, NIH, and The Center for Advancing Innovation launch start-up challenge to advance breast cancer biomedical inventions; student and entrepreneur mentor teams to develop strategic business plan and launch biotech start-up
NCI and Partners Release
(Posted: 09/19/2013) - A world-wide competition to bring emerging breast cancer technologies to market is being launched by the Avon Foundation for Women, in partnership with NCI and the Center for Advancing Innovation.

Researchers identify mechanisms that oversee the development of a pro-tumor network
NCI Cancer Center News
(Posted: 09/17/2013) - Researchers at Roswell Park Cancer Institute (RPCI) have uncovered a new pathway by which cancer cells, such as in breast cancer, stimulate the expansion of myeloid-derived suppressor cells (MDSCs), a blood cell population known to interfere with the body’s anti-tumor response. The findings, published online today in The Journal of Clinical Investigation, shed new light on the pathological events that fuel tumor growth and could lead to the development of new therapies to hinder it.

Sanford-Burnham researchers identify new target for melanoma treatment
NCI Cancer Center News
(Posted: 09/17/2013) - Scientists at Sanford-Burnham Medical Research Institute announced the discovery that a gene encoding an enzyme, phosphoinositide-dependent kinase-1 (PDK1), plays an essential role in the development and progression of melanoma. The finding, available in the advanced online publication of Oncogene, offers a new approach to treating this life-threatening disease.

New approach subtypes cancers by shared genetic effects
NCI Cancer Center News
(Posted: 09/16/2013) - Cancer tumors almost never share the exact same genetic mutations, a fact that has confounded scientific efforts to better categorize cancer types and develop more targeted, effective treatments. In a paper published in the September 15 advanced online edition of Nature Methods, researchers at the University of California, San Diego (home of the Moores Comprehensive Cancer Center) propose a new approach called network-based stratification (NBS), which identifies cancer subtypes not by the singular mutations of individual patients, but by how those mutations affect shared genetic networks or systems.

Study in mice finds decreased glucose metabolism increases immune potential
NCI News Note
(Posted: 09/16/2013) - Regulating glucose metabolism in immune cells may extend and enhance their ability to fight cancer and infection.

University of Southern California researchers find that a molecule quiets cancer cell chatter
NCI Cancer Center News
(Posted: 09/11/2013) - Researchers at the University of Southern California have found that a new compound interrupts the “conversation” between cancer cells to put the brakes on tumor growth.

Seven potential immunotherapy targets for treatment of melanoma identified
NCI News Note
(Posted: 09/10/2013) - NCI scientists, using a unique digital technology that counts RNA molecules in small amounts of tumor tissue, identified seven potential immunotherapy targets for treatment of melanoma.

Study uncovers value of mammogram screening for younger women
NCI Cancer Center News
(Posted: 09/09/2013) - A new analysis has found that most deaths from breast cancer occur in younger women who do not receive regular mammograms. Among 609 confirmed breast cancer deaths, 29 percent were among women who had been screened with mammography, while 71 percent were among unscreened women. The study, led by scientists at the Harvard Medical School in Boston (a component of the Dana-Farber Cancer Institute) was published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

Researchers uncover genetic cause of childhood leukemia
NCI Cancer Center News
(Posted: 09/09/2013) - For the first time, a genetic link specific to risk of childhood leukemia has been identified, according to a team of researchers from Memorial Sloan-Kettering Cancer Center, St. Jude Children's Research Hospital, University of Washington (an affiliate of the Fred Hutchinson Cancer Research Center), and other institutions. The discovery was reported online in the journal Nature Genetics.

Some immune cells appear to aid cancer cell growth
NCI Cancer Center News
(Posted: 09/06/2013) - The immune system is normally known for protecting the body from illness. But a subset of immune cells appear to be doing more harm than good. A new study from researchers at the University of Michigan Comprehensive Cancer Center found that these cells, called myeloid derived suppressor cells, provide a niche where the cancer stem cells survive.

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