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Proton therapy is a cost-effective treatment for pediatric brain tumor patients
NCI Cancer Center News
(Posted: 09/23/2013) - Proton therapy, an external beam radiotherapy in which protons deliver precise radiation doses to a tumor and spare healthy organs and tissues, is cost-effective in treating medulloblastomas, fast-growing brain tumors that mainly affect children, when compared to standard photon radiation therapy, according to research presented at the American Society for Radiation Oncology's (ASTRO's) 55th Annual Meeting by researchers from the Mount Auburn Hospital, the teaching hospital of Harvard Medical School (a component of the Dana-Farber Cancer Institute).

Sulfasalazine does not reduce diarrhea for patients receiving pelvic radiation therapy
NCI Cancer Center News
(Posted: 09/23/2013) - Patients receiving radiotherapy (RT) for cancers in the pelvic region can experience diarrhea, a negative side effect of radiation treatment. Sulfasalazine, an oral tablet used to treat inflammation of the bowels, had been shown in a past trial of 31 patients to decrease diarrhea during pelvic RT (Killic 2001). Sulfasalazine does not reduce diarrhea, according to research presented at the American Society of Radiation Oncology's (ASTRO's) 55th Annual Meeting by researchers from the Mayo Medical School and the Mayo Clinic. The study also determined that the medication may be associated with a higher risk of diarrhea than placebo.

Researchers at Washington U develop new models of drug-resistant breast cancer that hint at better treatments
NCI Cancer Center News
(Posted: 09/20/2013) - Researchers at Washington University School of Medicine in St. Louis have shown that human breast tumors transplanted into mice are excellent models of metastatic cancer and could be valuable tools in the search for better treatments.

Avon Foundation for Women, NIH, and The Center for Advancing Innovation launch start-up challenge to advance breast cancer biomedical inventions; student and entrepreneur mentor teams to develop strategic business plan and launch biotech start-up
NCI and Partners Release
(Posted: 09/19/2013) - A world-wide competition to bring emerging breast cancer technologies to market is being launched by the Avon Foundation for Women, in partnership with NCI and the Center for Advancing Innovation.

Researchers identify mechanisms that oversee the development of a pro-tumor network
NCI Cancer Center News
(Posted: 09/17/2013) - Researchers at Roswell Park Cancer Institute (RPCI) have uncovered a new pathway by which cancer cells, such as in breast cancer, stimulate the expansion of myeloid-derived suppressor cells (MDSCs), a blood cell population known to interfere with the body’s anti-tumor response. The findings, published online today in The Journal of Clinical Investigation, shed new light on the pathological events that fuel tumor growth and could lead to the development of new therapies to hinder it.

Sanford-Burnham researchers identify new target for melanoma treatment
NCI Cancer Center News
(Posted: 09/17/2013) - Scientists at Sanford-Burnham Medical Research Institute announced the discovery that a gene encoding an enzyme, phosphoinositide-dependent kinase-1 (PDK1), plays an essential role in the development and progression of melanoma. The finding, available in the advanced online publication of Oncogene, offers a new approach to treating this life-threatening disease.

New approach subtypes cancers by shared genetic effects
NCI Cancer Center News
(Posted: 09/16/2013) - Cancer tumors almost never share the exact same genetic mutations, a fact that has confounded scientific efforts to better categorize cancer types and develop more targeted, effective treatments. In a paper published in the September 15 advanced online edition of Nature Methods, researchers at the University of California, San Diego (home of the Moores Comprehensive Cancer Center) propose a new approach called network-based stratification (NBS), which identifies cancer subtypes not by the singular mutations of individual patients, but by how those mutations affect shared genetic networks or systems.

Study in mice finds decreased glucose metabolism increases immune potential
NCI News Note
(Posted: 09/16/2013) - Regulating glucose metabolism in immune cells may extend and enhance their ability to fight cancer and infection.

University of Southern California researchers find that a molecule quiets cancer cell chatter
NCI Cancer Center News
(Posted: 09/11/2013) - Researchers at the University of Southern California have found that a new compound interrupts the “conversation” between cancer cells to put the brakes on tumor growth.

Seven potential immunotherapy targets for treatment of melanoma identified
NCI News Note
(Posted: 09/10/2013) - NCI scientists, using a unique digital technology that counts RNA molecules in small amounts of tumor tissue, identified seven potential immunotherapy targets for treatment of melanoma.

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