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  • Posted: 11/20/2012
NCI Cancer Center News

Beth Israel study finds a 'code of silence' in acute myeloid leukemia

The development of acute myeloid leukemia (AML) is associated with a variety of genetic changes. Some of these alterations are epigenetic, wherein the sequence of the genes is unchanged, but chemical modifications to the DNA alter gene expression. In a study published in the Journal of Clinical Investigation, researchers led by Beth Israel Deaconess Medical Center found that a transcriptional regulator known as C/EBPG was highly expressed in a subset of AML samples that had an epigenetically silenced C/EBPA gene. The Beth Israel Deaconess Medical Center is a component of the Dana-Farber Cancer Institute.

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