Huntsman Cancer Institute makes new discovery about DNA packaging
Chromatin remodeling complexes (CRCs) are cellular protein complexes that behave like motors, expanding or compacting different portions of DNA to either express or silence genes. Previously, scientists thought that the motor within CRCs waits at rest until it receives instructions. New research from the Huntsman Cancer Institute shows that the motor within a key CRC responsible for gene packaging and assembly is intrinsically turned on, and instead requires specific instructions to turn it off.
Among the research institutions NCI funds across the United States, it currently designates 67 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer’s origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers’ research results are often at the forefront of studies in the cancer field.