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NCI Cancer Center News

Huntsman Cancer Institute makes new discovery about DNA packaging

  • Posted: November 19, 2012

Chromatin remodeling complexes (CRCs) are cellular protein complexes that behave like motors, expanding or compacting different portions of DNA to either express or silence genes. Previously, scientists thought that the motor within CRCs waits at rest until it receives instructions. New research from the Huntsman Cancer Institute shows that the motor within a key CRC responsible for gene packaging and assembly is intrinsically turned on, and instead requires specific instructions to turn it off.

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