In multi-institute study, heat-shock factor reveals its unique role in supporting highly malignant cancers
A study led by Whitehead Institute researchers has found that increased expression of a specific set of genes is strongly associated with metastasis and death in patients with breast, colon, and lung cancers. Not only could this finding help scientists identify a gene profile predictive of patient outcomes and response to treatment, it could also guide the development of therapeutics to target multiple cancer types. This study included researchers from Brigham and Women's Hospital, the Massachusetts Institute of Technology, the Howard Hughes Medical Institute, the Harvard School of Public Health, and the University of Miami Miller School of Medicine.
Among the research institutions NCI funds across the United States, it currently designates 67 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer’s origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers’ research results are often at the forefront of studies in the cancer field.