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  • Posted: 04/06/2012
NCI Cancer Center News

Roswell Park-led study finds vitamin D influences racial differences in breast cancer risk

American women of African ancestry are more likely than European Americans to have estrogen-receptor-negative (ER-negative) breast cancer. There continues to be discussion about the role of low levels of vitamin D in the development of breast cancer for these women. New research by a team from Roswell Park Cancer Institute (RPCI) and four other institutions has shown that specific genetic variations in the vitamin D receptor (VDR) and in CYP24A1 (responsible for deactivating vitamin D) are associated with an increase in breast cancer risk — particularly for ER-negative breast cancer — for African-American women.

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