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  • Posted: 09/06/2012
NCI Cancer Center News

Penn study finds tension on gut muscles induces cell invasion in zebrafish intestine, mimicking cancer metastasis

Researchers at the Perelman School of Medicine, University of Pennsylvania, and colleagues, show that epithelial cells lining the intestine of zebrafish that carry an activating mutation of the smooth muscle myosin gene form protrusions called invadopodia that allow the cells to invade surrounding connective tissue. The epithelial cell protrusions form in response to non-regulated contractions in the surrounding smooth muscle cells. These contractions generate oxidative stress in the epithelial cells, which has been linked to invadopodia formation in human cancer cells. The University of Pennsylvania is home to the Abramson  Cancer Center.

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