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St. Jude-led study finds new genetic defects in high-risk childhood leukemia subtypes

  • Posted: January 22, 2013

Research led by St. Jude Children’s Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes. The findings also provide the first evidence of the genetic basis for this high-risk leukemia, which is known as hypodiploid acute lymphoblastic leukemia (ALL). St. Jude researchers led the study in collaboration with investigators from the Children’s Oncology Group, the world’s largest organization devoted exclusively to childhood and adolescent cancer research. The study's whole genome sequencing was done in conjunction with the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project.

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