UCSD study illuminates how cells know when it’s time to eat themselves
Researchers at the University of California, San Diego School of Medicine and the Moores Comprehensive Cancer Center have identified a molecular mechanism regulating autophagy, a fundamental stress response used by cells to help ensure their survival in adverse conditions. The researchers report that an enzyme called AMPK, typically involved in sensing and modulating energy use in cells, also regulates autophagic enzymes. Failure of normal autophagy has been associated with accumulated cell damage and aging.
Among the research institutions NCI funds across the United States, it currently designates 67 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer’s origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers’ research results are often at the forefront of studies in the cancer field.