Cold Spring Harbor scientists determine mechanism of one of the most powerful tumor-suppressor proteins, Chd5
A team of cancer researchers at Cold Spring Harbor Laboratory (CSHL) has solved the mystery of how one of the most powerful of the body’s natural tumor-suppressing proteins, called Chd5, exerts its beneficial effects. The findings, published online in the journal Cell Reports, are important because Chd5 engages processes fundamental to cancer prevention. Conversely, when Chd5 is mutated or missing, an important door is opened to cancer initiation.
Among the research institutions NCI funds across the United States, it currently designates 67 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer’s origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers’ research results are often at the forefront of studies in the cancer field.