Case Western study links molecule to late-stage breast cancer
Prior to this study, from Case Western Reserve University School of Medicine and the Case Comprehensive Cancer Center, published online in the Journal of Clinical Investigation, the ribonucleic acid (RNA) molecule called miR-181a had never before been tied to breast cancer metastasis—but when scientists found elevated levels of the molecule in late-stage breast cancer tissues, they tested an inhibitor in mouse models. The approach not only prevented metastasis, but also extended the animals’ lives.
Among the research institutions NCI funds across the United States, it currently designates 67 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer’s origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers’ research results are often at the forefront of studies in the cancer field.