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VOLUME 1, ISSUE 1
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Animation/Video

TRANSCRIPT: 2. Deletion Mutation


[Animation clip begins by zooming in on a vertically oriented DNA helix set on an empty black background. The helix is comprised of two ribbon-like vertical spiraling blue structures, each of which has a series of colored rungs running its entire length. The rungs, or bases, which extend horizontally from each spiral, are red, yellow, green and purple. The bases on one spiral are bound to those on the other, creating horizontal base pairs that connect the two spirals. The base pairs are matched by color: red/green and yellow/purple. The bases are also shaped differently, so that a red base fits exclusively into a green base and a purple base fits exclusively into a yellow base.]

Instead of fully copying a DNA strand, the copier strand cannot copy bases that are missing on the DNA.

[Messenger RNA, shown as a spiraling ribbon-like purple structure, creates matching base pairs on half of the helix, but no connection occurs where there is a missing base.]

What results is called an oncogene, which is a mutated gene which may have missing base pairs or other abnormalities. The oncogene is then processed by something called a ribosome, shown here as a large blue structure [The Messenger RNA moves away from the DNA helix and toward a ribosome, shown here as a large blue structure].

The resulting protein will have abnormalities, depicted here as transparent globes, which can lead to cancer.

[The Messenger RNA enters the left side of the ribosome. A string of red, blue, green, and purple globes emerge from the right side. Transparent, colorless globes are interspersed among the colored globes].


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