National Cancer Institute National Cancer Institute
U.S. National Institutes of Health National Cancer Institute
NCI Home Cancer Topics Clinical Trials Cancer Statistics Research & Funding News About NCI
IN THIS ISSUE
Defining Cancer Gene by Gene

Genes Recently Identified

Animation/VideoAnimation/Video

Photos/StillsPhotos/Stills

USEFUL CANCER BACKGROUND
Understanding Cancer Series
Show-and-Tell Tutorials

------

NCI Fact Sheets
Briefs on Cancer Topics

------

NewsCenter
Press Releases

------
SEARCH BENCHMARKS
   
  Between these Dates:      
     
     
Search Benchmarks  
    View All Issues  

MEDIA RESOURCES
Noticias En Español

Understanding Cancer Series

Visuals Online

B-Roll Footage

Radio Broadcasts

Entertainment Resources

Go To Benchmarks Home Page...
Benchmarks
------
VOLUME 1, ISSUE 1
------
Animation/Video

TRANSCRIPT: 5. Cell Growth and Repair


[Animation clip begins with a close view of a vertically oriented DNA helix set on an empty black background. The helix is comprised of two ribbon-like vertical spiraling blue structures, each of which has a series of colored rungs running its entire length. The rungs, or bases, which extend horizontally from each spiral, are red, yellow, green and purple. The bases on one spiral are bound to those on the other, creating horizontal base pairs that connect the two spirals. The base pairs are matched by color: red/green and yellow/purple. The bases are also shaped differently, so that a red base fits exclusively into a green base and a purple base fits exclusively into a yellow base. In addition to the uniform base pairs, the DNA helix also displays a mutated base pair, made up of a small grey diamond-shaped base paired with a large yellow hexagon, and two bases on one blue spiral, a purple base and a yellow base, that do not have matching nodes on the other blue spiral, creating a gap in the connections.]

In all three of our examples, something went wrong--the DNA lead to a mutated RNA copy and formation of new mutated or cancerous cells arose.

[The view zooms out until the DNA helix fades into the center of a cancer cell, depicted as an asymmetrical greyish-blue mass with a darker blue center. Two of these structures appear, joined by their greyish-blue layers, on a background of healthy cells, depicted as asymmetrical pink masses with purple centers. The cancer cells separate into two distinct cells. The shot pulls back as the cancer cells continue to multiply, covering the healthy cells.]

Cancer cells divide at a much quicker rate than normal cells, forming irregularly sized cells with enlarged nuclei. As cancer cells continue to divide, they form masses called tumors.

[The shot continues to pull back until the cancer cells appear as a greyish-blue mass on the left side of a person's chest. A white circle, representing an implanted surgical port, is surrounded by concentric grey circles and appears on the person's chest. A white syringe appears and moves in to inject...]

Tumors can sometimes be treated with new molecular agents such as the breast cancer drug Herceptin. This drug can be injected into a patient to try and repair the DNA copying process that got out of control, destroy the tumor so that only normal cells remain and future cell division only originates from normal, unmutated DNA.

[The shot zooms in on the person's chest until normal cells reappear, and continues to close in until a normal, unmutated helix is seen.]


A Service of the National Cancer Institute
Department of Health and Human Services National Institutes of Health USA.gov