Animation/Video
TRANSCRIPT: 5. Cell Growth and Repair
[Animation clip begins with a close view of a vertically oriented DNA helix
set on an empty black background. The helix is comprised of two ribbon-like
vertical spiraling blue structures, each of which has a series of colored rungs
running its entire length. The rungs, or bases, which extend horizontally from
each spiral, are red, yellow, green and purple. The bases on one spiral are
bound to those on the other, creating horizontal base pairs that connect the
two spirals. The base pairs are matched by color: red/green and yellow/purple.
The bases are also shaped differently, so that a red base fits exclusively into
a green base and a purple base fits exclusively into a yellow base. In addition
to the uniform base pairs, the DNA helix also displays a mutated base pair,
made up of a small grey diamond-shaped base paired with a large yellow hexagon,
and two bases on one blue spiral, a purple base and a yellow base, that do not
have matching nodes on the other blue spiral, creating a gap in the connections.]
In all three of our examples, something went wrong--the DNA lead to a mutated
RNA copy and formation of new mutated or cancerous cells arose.
[The view zooms out until the DNA helix fades into the center of a cancer
cell, depicted as an asymmetrical greyish-blue mass with a darker blue center.
Two of these structures appear, joined by their greyish-blue layers, on a background
of healthy cells, depicted as asymmetrical pink masses with purple centers.
The cancer cells separate into two distinct cells. The shot pulls back as the
cancer cells continue to multiply, covering the healthy cells.]
Cancer cells divide at a much quicker rate than normal cells, forming irregularly
sized cells with enlarged nuclei. As cancer cells continue to divide, they form
masses called tumors.
[The shot continues to pull back until the cancer cells appear as a greyish-blue
mass on the left side of a person's chest. A white circle, representing an implanted
surgical port, is surrounded by concentric grey circles and appears on the person's
chest. A white syringe appears and moves in to inject...]
Tumors can sometimes be treated with new molecular agents such as the breast
cancer drug Herceptin. This drug can be injected into a patient to try and repair
the DNA copying process that got out of control, destroy the tumor so that only
normal cells remain and future cell division only originates from normal, unmutated
DNA.
[The shot zooms in on the person's chest until normal cells reappear, and
continues to close in until a normal, unmutated helix is seen.] |