News Notes: Two Proteins May Be Key to Screening for Early-Stage Liver Cancer
Researchers have identified an improved method of screening high-risk patients for one of the most common types of liver cancer, hepatocellular carcinoma(HCC), particularly if the patient has a history of hepatitis. By changing the threshold of one commonly used screening test and adding a second, complementary test, researchers were able to accurately identify more early stage HCC cases. There is currently no standard or routine screening test for HCC, but high-risk patients (i.e. those with a history of hepatitis infection or cirrhosis) are often tested for high levels of Alpha-fetoprotein (AFP), a protein which is usually produced by a fetus, and in adults can indicate the presence of HCC. Blood levels of AFP can be elevated for other reasons, however, such as pregnancy, hepatitis, and other forms of cancer.
A multi-institutional team of researchers from the NCI's Early Detection Research Network (EDRN) compared the efficacy of AFP with two other proteins, des-gamma carboxyprothrombin (DCP) and lectin-bound alpha-fetoprotein (AFP-L3), which are also associated with liver cancer. They found that AFP was the best choice for finding early stage HCC. In addition, they found that screening for the presence of both AFP and DCP together was best when screening for early stage HCC that is associated with hepatitis infection. The results of this study were published July 1, 2009, in the journal Gastroenterology. The abstract of the article, α-Fetoprotein, Des-γ Carboxyprothrombin, and Lectin-Bound α-Fetoprotein in Early Hepatocellular Carcinoma can be viewed online.