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  • Posted: 12/12/2012

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NCI News Note

NCI Central Institutional Review Board Receives Accreditation

The Association for the Accreditation of Human Research Protection Programs (AAHRPP) has awarded the National Cancer Institute Central Institutional Review Board (CIRB) full accreditation. AAHRPP awards accreditation to organizations demonstrating the highest ethical standards in clinical research. Achieving accreditation establishes that the NCI CIRB has robust review processes in place to ensure the safety and protection of people who participate in NCI-funded clinical studies.

In conjunction with accreditation, the NCI CIRB is changing to an independent review model. Under this model, the CIRB is the IRB of record.  Now, research sites in different locales that have joined the NCI CIRB will be able to rely solely on the CIRB to meet all IRB regulatory requirements.  A pilot of the independent model was performed in 22 sites that conduct clinical research during the past year. Results from the evaluation of the pilot showed participants enthusiastically supported the independent model.  This model further reduces the administrative burden necessary to open multi-institutional, NCI-funded clinical trials and assists the restructuring of the NCI national clinical trials network, which aims to reduce the length of time it takes to complete cancer clinical trials and bring new cancer treatments to patients.  Key strengths of the newly accredited NCI CIRB include: recognition of the high quality of review; reduced workload at the local level; faster times to the start of accrual for trials; and the ability to offer more clinical trials.