Oncogene mutation hijacks splicing process to promote growth and survival
An international team of researchers – led by researchers from the Ludwig Institute for Cancer Research and the Department of Pathology at the University of California, San Diego School of Medicine (home of the Moores Comprehensive Cancer Center) – has found that a singular gene mutation helps brain cancer cells to not just survive, but grow tumors rapidly by altering the splicing of genes that control cellular metabolism. The findings are published online in the journal Cell Metabolism.
Among the research institutions NCI funds across the United States, it currently designates 67 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer’s origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers’ research results are often at the forefront of studies in the cancer field.