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  • A xenograph model of green fluorescent protein of breast cancer cells implanted in the mammary fat pad of female nude mouse. The slide that shows NOS2 being targeted with drug; the slide background is black and  NOS2 appears in orange and purple blotches.
    Study in mice shows that an aggressive type of breast cancer is linked to an inflammatory protein
    NCI News Note

    (Posted: 04/14/2014) - Aberrant expression of an inflammatory protein, nitric oxide synthase 2 (NOS2), may enhance the progression and metastasis of an aggressive and less common form of breast cancer, known as the estrogen receptor-negative type of disease.

  • An Open Letter to the Cancer Community Regarding Community Clinical Trials

    (Posted: 04/11/2014) - The National Cancer Institute (NCI) is in the process of combining its two community-based research networks to create a single network that builds on the strengths of the Community Clinical Oncology Program/Minority-Based Community Clinical Oncology Program (CCOPs) and the NCI Community Cancer Centers Program (NCCCP).

  • NCI intramural research highlighted at 2014 AACR meeting
    NCI Perspective Article

    (Posted: 04/07/2014) - This year’s American Association for Cancer Research meeting featured plenary talks by two NCI scientists, Steven Rosenberg, M.D., and Louis Staudt, M.D., Ph.D., that highlighted the challenges in developing varied and potentially synergistic treatments for aggressive forms of cancer. Each researcher has been focusing primarily on a particularly difficult to treat cancer (melanoma and lymphoma, respectively) for many decades, and their presentations highlight the diligence and tenacity needed to come to a better understanding of the cancer process and to find effective agents to target the diseases they study.

  • Statement on Forthcoming Changes in NCI's Clinical Trials Programs

    (Posted: 04/04/2014) - Clinical trials are pivotal elements in the conversion of scientific discoveries into practical means to prevent and treat cancers.
    View the article in Spanish

  • Two women in white lab coats in a research lab pose in front of lab equipment.
    Breast Cancer Startup Challenge announces ten winning teams of entrepreneurs; Promising technologies identified to speed cancer research
    NCI Press Release

    (Posted: 03/05/2014) - Ten winners of a world-wide competition to bring emerging breast cancer research technologies to market faster were announced today by the Avon Foundation for Women, in partnership with NCI and the Center for Advancing Innovation (CAI). Avon is providing $250,000 in funding for this Challenge.

  • Drawing of a section of a man’s chest that includes nipple and areola.
    NIH study confirms risk factors for male breast cancer
    NCI News Note

    (Posted: 02/19/2014) - Pooled data from studies of about 2,400 men with breast cancer and 52,000 men without breast cancer confirmed that risk factors for male breast cancer include obesity, a rare genetic condition called Klinefelter syndrome, and gynecomastia.

  • A glass bottle of aspirin with a white, yellow and brown label.
    NIH study finds regular aspirin use may reduce ovarian cancer risk
    NCI Press Release

    (Posted: 02/06/2014) - Women who take aspirin daily may reduce their risk of ovarian cancer by 20 percent, according to a study by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health. However, further research is needed before clinical recommendations can be made. The study was published Feb. 6, 2014, in the Journal of the National Cancer Institute.
    View the article in Spanish

  • Drawing of a glioma in the brain, showing a cross-section of the brain and a yellow mass where the tumor could occur in the brain.
    Adding chemotherapy following radiation treatment improves survival for adults with a slow-growing type of brain tumor
    NCI Press Release

    (Posted: 02/03/2014) - Adults with low-grade gliomas, a form of brain tumor, who received chemotherapy following completion of radiation therapy lived longer than patients who received radiation therapy alone, according to long-term follow-up results from a NIH-supported randomized controlled clinical trial. Low-grade gliomas have a more indolent or slower growing behavior and better outcome compared to the more common high-grade gliomas such as glioblastoma. [Image copyright Mayo Clinic, 2012]
    View the article in Spanish

  • MPACT Logo
    NCI launches trial to assess the utility of genetic sequencing to improve patient outcomes
    NCI Press Release

    (Posted: 01/30/2014) - A pilot trial to assess whether assigning treatment based on specific gene mutations can provide benefit to patients with metastatic solid tumors is being launched this month by the NCI. The Molecular Profiling based Assignment of Cancer Therapeutics, or M-PACT, trial is one of the first to use a randomized trial design to assess if assigning treatment based on genetic screening can improve the rate and duration of response in patients with advanced solid tumors.
    View the article in Spanish

  • A graphic generated by a computer of the structure of DNA in the B form.  Red, blue, yellow and light blue balls indicate the 4 bases that comprise the DNA double-helix
    TCGA bladder cancer study reveals potential drug targets, similarities to several cancers
    NCI Press Release

    (Posted: 01/29/2014) - Investigators with TCGA have identified new potential therapeutic targets for a major form of bladder cancer, including important genes and pathways that are disrupted in the disease. They also discovered that, at the molecular level, some subtypes of bladder cancer resemble subtypes of breast, head and neck and lung cancers, suggesting similar routes of development.

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